针对晚期子宫内膜癌的向治疗:专注于Pembrolizumab
Nathan El-Ghazzi1, Xavier Durando1,2,3,4, Alexia Giro2,3,4
1Oncology Department, Centre Jean Perrin, Clermont-Ferrand, France.
OncoTargets and therapy
|June 8, 2023
概括
晚期子宫内膜癌 (EC) 的生存率很差,但新的治疗方法提供了希望. 免疫检查点抑制剂,如pembrolizumab,单独或与lenvatinib,显示前途的高级或转移性EC,无论分子形状.
科学领域:
- 妇科瘤学 妇科瘤学
- 癌症基因组学 癌症基因组学
- 免疫治疗是一种免疫疗法.
背景情况:
- 子宫内膜癌 (EC) 在晚期预后不佳,五年生存率仅为17%. 最近的进展包括基于癌症基因组图谱 (TCGA) 数据的EC分子分类,识别了POLE突变,微卫星不稳定性高 (MSI-H) /缺陷不匹配修复 (dMMR),TP53突变等亚型,并且没有特定的分子形状.
- 晚期EC的传统治疗方法,包括化疗和激素治疗,有效性有限.
研究的目的:
- 审查晚期子宫内膜癌治疗的最新进展,重点关注免疫检查点抑制剂 (ICI) 的影响.
- 突出重复性和转移性EC的不断变化的治疗环境,包括新药组合和未来方向.
主要方法:
- 对目前关于子宫内膜癌治疗的文献和临床试验数据的审查.
- 分析免疫检查点抑制剂 (ICI) 和针对性治疗在先进的EC疗法的疗效.
- 讨论新兴生物标志物和新型组合疗法.
主要成果:
- 布罗利祖马布 (抗PD-1) 已被批准作为二线设置中的dMMR/MSI-H高级EC的单疗法.
- 伦瓦提尼布和潘布罗利祖马布的组合提供了一个有效的二线选择,用于高级的EC,无论MMR状态如何.
- 目前正在进行的试验正在评估lenvatinib加pembrolizumab作为前线治疗,并探索pembrolizumab与化疗,PARP抑制剂和氨酸激酶抑制剂的其他组合.
结论:
- 免疫检查点抑制剂显著提高了先进和转移性子宫内膜癌的管理.
- 新的疗法组合,包括伦瓦替尼和班布罗利祖马布,为患有晚期结核病的患者提供了新的治疗机会.
- 需要进一步的研究来确定可靠的生物标志物并优化EC的治疗策略.
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