粉红色皮病中的血清介质素-36:疾病严重程度的潜在生物标志物
Eman M Sanad1, Mays Ibrahim2, Maha Rachwan3
1Dr. Sanad and Dr. Shams are with the Department of Dermatology, Venereology and Andrology, and Faculty of Medicine at Benha University, in Banha, Egypt.
The Journal of clinical and aesthetic dermatology
|June 8, 2023
概括
血清IL-36水平在粉红色皮病 (PR) 患者中升高,与疾病严重程度相关. 这表明IL-36可能作为PR的潜在生物标志物.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 粉红色皮 (PR) 是一种急性,自我限制的皮肤皮疹,原因不明.
- 细胞因子在PR病原体中的作用尚不清楚.
- 研究PR中的细胞因子概况可以提供对疾病机制的洞察.
研究的目的:
- 为了测量PR患者血清中的中白素-36 (IL-36) 水平.
- 为了确定IL-36水平和PR的严重程度之间的关系.
- 探索IL-36作为PR的潜在生物标志物.
主要方法:
- 一项涉及40名PR患者和40名健康对照者的病例控制研究.
- 使用Pityriasis Rosea严重程度评分 (PRSS) 来评估疾病的严重程度.
- 酶相关免疫吸收试验 (ELISA) 用于量化血清IL-36水平.
主要成果:
- 与对照组 (18.76±10.24 pg/mL) 相比,PR患者的血清IL-36水平显著更高 (30.36±12.35 pg/mL).
- IL-36水平与PRSS得分呈正相关性 (r=0.627,P=0.003). 这表明IL-36水平与PRSS得分呈正相关性 (r=0.627,P=0.003).
- 患有COVID-19病史的患者的IL-36水平明显升高.
结论:
- 血清IL-36的升高与pityriasis rosea相关.
- IL-36水平与PR的临床严重程度相关.
- 血清IL-36可能作为pityriasis rosea.的有价值的生物标志物.
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