固体器官移植后骨质疏松症和骨折的高风险:一个基于人口的研究
Hsin Chen1,2, Yung-Rung Lai3,4, Yih Yang5
1School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Frontiers in endocrinology
|June 8, 2023
概括
固体器官移植 (SOT) 接受者面临骨质疏松症和骨折的风险增加. 心脏或肺移植患者,以及61岁以上的患者,特别容易受到这些骨疾病的影响.
科学领域:
- 医学研究 医学研究
- 移植医学是一种移植医学.
- 骨的健康 骨的健康
背景情况:
- 骨质疏松症和骨折对固体器官移植 (SOT) 受体的发病率和死亡率构成重大风险.
- 有限的研究已经探索了骨质疏松症和SOT后骨折的特定风险.
研究的目的:
- 调查各种固体器官移植受体骨质疏松症和病理骨折的风险.
- 将这些风险与一般人口队列进行比较.
主要方法:
- 使用台湾国家数据库进行的回顾性队列研究.
- 倾向性得分匹配以创建一个比较队列,不包括先前存在的骨质疏松症或骨折诊断.
- 考克斯的比例危险模型分析风险,并跟踪直到诊断,死亡或2018年底.
主要成果:
- 与普通人群相比,接受SOT的人患骨质疏松症 (HR=1.46) 和骨折 (HR=1.19) 的风险更高.
- 接受心脏或肺移植的人患骨折风险最高 (HR=4.62).
- 61岁以上的患者表现出骨质疏松症 (HR=11.51) 和骨折 (HR=11.75) 的最高风险.
结论:
- 固体器官移植受体患有骨质疏松症和骨折的风险较高.
- 最高的风险与心脏/肺移植,年龄较大 (>61岁),并具有较高的并发症评分 (CCI >3) 相关.
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