从康复者双抗原特异性B细胞生成的针对SARS-CoV-2的强效中和性宽谱抗体
Masaru Takeshita1, Hidehiro Fukuyama2,3,4,5, Katsuhiko Kamada6
1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
iScience
|June 8, 2023
概括
研究人员开发了针对SARS-CoV-2变种的广泛中和抗体. 这些抗体在临床前模型中显示出治疗潜力,降低了感染仓鼠的病毒载量.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 开发治疗性抗体 开发治疗性抗体
背景情况:
- 现有的SARS-CoV-2抗体治疗药物对新兴变异的疗效有所降低.
- 广泛中和抗体的开发对于对抗病毒进化至关重要.
研究的目的:
- 为了产生和表征新型,广泛中和抗体对抗SARS-CoV-2.
- 在临床前模型中评估这些抗体的治疗潜力.
主要方法:
- 来自康复期个体的B细胞被用来产生针对武汉和玛变异SARS-CoV-2受体结合域的抗体.
- 对各种SARS-CoV-2菌株进行了抗体中和活性测试,包括Omicron子菌株.
- 结构分析确定了结合模式,并在子感染模型中测试了一种代表性抗体.
主要成果:
- 在172个产生的抗体中,有6个中和了所有Omicron前菌株.
- 五种抗体对一些Omicron亚菌株表现出活性.
- 一种经过修改的抗体在低剂量 (2毫克/公斤) 时显著降低了仓鼠的肺病毒标位.
结论:
- 开发的抗体表现出广泛的中和活性和抗病毒功效.
- 这项研究强调了细胞查策略对于有效治疗抗体开发的重要性.
- 这些抗体代表了SARS-CoV-2治疗干预的有希望的候选人.
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