高度区域选择性和散列选择性合成新型的pyrazinoindolones
Maryam Tajik1, Morteza Shiri1, Faiq H S Hussain2
1Department of Organic Chemistry, Faculty of Chemistry, Alzahra University Vanak Tehran 1993893973 Iran mshiri@alzahra.ac.ir.
RSC advances
|June 8, 2023
概括
一种新的无金属合成创建了功能化的pyrazino indole衍生物使用Ugi反应添加物. 这种高效的基质介导方法为复杂的多环化合物提供了一条实用的途径.
科学领域:
- 有机化学 有机化学
- 药用化学 医学化学
- 合成化学 合成化学
背景情况:
- 乌吉反应是一种多用途的多元组分反应,用于合成复杂分子.
- 皮拉齐诺[1,2-a]醇支架存在于各种生物活性化合物中.
- 在现代有机化学中,开发高效且无金属的合成路径至关重要.
研究的目的:
- 开发一种高效的基质介导,无金属合成的1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]英多-3-carboxamide衍生物.
- 为了探索新 bis-amide Ugi-adducts 的分子内英多尔 N-H 化.
- 为制备具有高区域选择性的新型多环函数化pyrazino衍生物.
主要方法:
- 通过Ugi反应合成新的bis-amide Ugi附加物.
- 使用 (E) - 肉甲衍生物,2-chloroaniline,英多尔-2-碳酸和异化物.
- 在100°C时通过二甲基硫氧化物 (DMSO) 中的碳酸 (Na2CO3) 促进的分子内N-H化.
主要成果:
- 成功合成了1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]英多尔-3-碳胺衍生物.
- 展示一种实用且高度区域选择性的新型多环函数化pyrazino衍生物制剂.
- 建立一个高效的基质介导和无金属合成协议.
结论:
- 开发的方法提供了一条高效和实用的途径,用于新型pyrazino[1,2-a]indole衍生物.
- 该研究强调了Ugi-adducts在构建复杂的多环系统中的实用性.
- 这种无金属的方法为有机化学中可持续和可扩展的合成提供了优势.
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