在海绵中,身体规划的重组与微生物组的变化有关
Sergio Vargas1, Laura Leiva1, Michael Eitel1
1Department of Earth and Environmental Sciences, Palaeontology & Geobiology, Ludwig-Maximilians-Universität München, München, Germany.
Molecular biology and evolution
|June 8, 2023
概括
由于共生蓝菌的损失导致海绵漂白,引发了显著的身体计划变化并影响了基因表达. 这突显了动物发育与微生物群健康之间的深层进化联系.
科学领域:
- 海洋生物学 海洋生物学
- 发展生物学 发展生物学
- 微生物组研究 微生物组研究
背景情况:
- 动物与微生物群的相互作用对发育至关重要.
- 微生物组的干扰可能会影响动物生理学和形态学.
- 海绵是共生微生物的宿主,包括蓝藻细菌.
研究的目的:
- 调查光合作生体丧失 (漂白) 对海绵形态和发育的影响.
- 评估经历微生物组破坏的海绵中的转录和微解剖学变化.
- 探索动物微生物组通信的进化起源.
主要方法:
- 对阴影 (漂白) 和对照海绵 (Lendenfeldia chondrodes) 的形态和微解剖学比较分析.
- 转录组分析以确定基因表达的变化.
- 专注于参与形态发生和免疫的信号通路.
主要成果:
- 阴影诱导漂白和从叶状变为线状形态的转变.
- 微解剖学发生了变化,皮质减少,可阿诺索姆发育.
- 观察到显著的转录组变化,包括Wnt,TGF-β和TLR-ILR通路的调节.
结论:
- 在海绵中微生物群的崩导致了深刻的形态和遗传重组.
- 在海绵的转录基因状态和其微生物组之间存在强烈的合.
- 这种相互作用表明,动物微生物组反应的古老进化根源.
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