水素离子调动模型在血液透析过程中的有效性与时间依赖的透析酸二碳酸盐度
John Kenneth Leypoldt1, Mauro Pietribiasi1, Malgorzata Debowska1
1Nalecz Institute of Biocybernetics and Biomedical Engineering Polish Academy of Sciences, Poland.
The International journal of artificial organs
|June 8, 2023
概括
离子 (H+) 调动模型准确地描述了血液二碳酸盐动力学在血液透析 (HD),即使在改变透析度. 这个模型这个模型.
科学领域:
- 腎臟病學和透析.
- 生物医学工程 生物医学工程
- 生理学建模 生理学建模
背景情况:
- 离子 (H+) 调动模型先前在血液透析 (HD) 中验证了血液二碳酸盐 (HCO3) 动力学,使用恒定透析物[HCO3].
- 这项研究研究了模型的有效性与动态的,时间依赖的透析剂[HCO3]度.
研究的目的:
- 评估H+调动模型在使用可变透析剂[HCO3]治疗时描述血液HCO3动态的能力.
- 为了评估模型在不同透析二碳酸盐条件下的预测准确度.
主要方法:
- 利用了从20名经历了4小时治疗的慢性HD患者的临床数据.
- 采用非线性回归来确定H+调动模型参数 (Hm) 对于恒定,递减和递增的透析剂[HCO3].
- 分析了114个HD治疗方法来估计Hm和评估模型适合.
主要成果:
- 对H+调动参数 (Hm) 的估计在恒定,减少或增加透析剂[HCO3]治疗中没有显著差异 (p=0.26).
- 测量和预测血液[HCO3]之间的二次差异之和在治疗类型之间没有显著差异 (p=0.50).
- 标志着无论透析剂[HCO3]的变化如何,都能保持一致的模型匹配度.
结论:
- +调动模型证明了它对于描述血液中HCO3动态的有效性.
- 该模型在HD期间使用时间依赖透析剂[HCO3]时也保持了恒定Hm值的准确性.
更多相关视频
07:38Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane
Published on: March 30, 2015
9.3K
10:00Use of Enzymatic Biosensors to Quantify Endogenous ATP or H2O2 in the Kidney
Published on: October 12, 2015
12.0K
相关概念视频
Polyprotic Acids
29.3K
Acids are classified by the number of protons per molecule that they can give up in a reaction. Acids such as HCl, HNO3, and HCN that contain one ionizable hydrogen atom in each molecule are called monoprotic acids. Their reactions with water are:
29.3K
Bicarbonate-Carbonic Acid Buffer
1.7K
The carbonic acid-bicarbonate buffer system is critical for maintaining the body's pH balance. It operates on the equilibrium:
1.7K
Renal Regulation of Acid-Base Balance
529
Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
529
Roles of Electrolytes: Chloride and Bicarbonate
276
Chloride ions contribute to the osmotic pressure gradient distinguishing the intracellular fluid (ICF) from the extracellular fluid (ECF). They counterbalance positively charged ions in the ECF and ensure its electrochemical stability. The renal system's process of chloride absorption and release generally mirrors that of sodium ions.
Conditions such as hypochloremia can arise from insufficient chloride reabsorption by the kidneys, often compounded by extended bouts of diarrhea, vomiting,...
Conditions such as hypochloremia can arise from insufficient chloride reabsorption by the kidneys, often compounded by extended bouts of diarrhea, vomiting,...
276
Henderson-Hasselbalch Equation
69.5K
The ionization-constant expression for a solution of a weak acid can be written as:
69.5K
Dialysis
737
Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
737
