性类固醇暴露的生理性下降与健康男性身体组成的变化相关 - - 一项前性队列研究
Thiberiu Banica1,2, Charlotte Verroken1, Tim Reyns3
1Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
European journal of endocrinology
|June 8, 2023
概括
在健康的男性中,衰老会增加身体脂肪和胰岛素抵抗. 性类固醇水平随着身体脂肪变化而变化,而不是随着肌肉质量或力量变化.
科学领域:
- 内分泌学 在内分泌学.
- 人体生理学 人体生理学
- 代谢健康 代谢健康
背景情况:
- 雄激素水平自然会随着年龄的增长而下降,男性的体重指数较高的男性下降更为急剧.
- 随着时间的推移,健康男性的身体组成,代谢变化和性类固醇水平之间的关系尚未完全理解.
研究的目的:
- 在健康的成年男性中,研究与性类固醇水平相关的身体组成和代谢健康的纵向变化.
- 确定衰老如何影响性激素水平及其与人体组成和代谢标记物的关联.
主要方法:
- 这是一项基于人口的长度研究,对676名24至46岁的健康男性进行研究,在基线和12年后进行测量.
- 评估了血清性激素结合球蛋白 (SHBG), (T),雌激素 (E2),二,计算的自由T,计算的自由E2 (cFE2),以及对胰岛素抵抗的恒温模型评估 (HOMA-IR).
- 使用双能X射线吸收度和外围定量计算机断层扫描测量身体组成,以及握力.
主要成果:
- 在12年内,平均脂肪量 (FM),瘦肉量 (LM) 和HOMA-IR显著增加.
- 降低雄激素和SHBG水平与增加FM相关,而降低cFE2与降低FM相关.
- 降低cFE2和增加SHBG水平与下降的LM有关.
结论:
- 老龄化与男性脂肪量增加和胰岛素抵抗有关.
- 健康男性的性类固醇水平显然与脂肪的变化有关,而不是与瘦身量,胰岛素抵抗或握力有关.
- 随着时间的推移,瘦体质参数的变化不如脂肪质量的变化那么明显.
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