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Hadeel Elzeny¹, Wegdan Mohamed², Enas Daef²

¹Assiut International Center of Nanomedicine, Al-Rajhy Hospital, Assiut, Egypt.

Journal of medical microbiology

|June 8, 2023

概括

在埃及,广泛耐药的高病毒性Klebsiella肺炎 (hvKP) 主导着呼吸机相关肺炎 (VAP). 这项研究揭示了XDR-hvKP的克隆传播,强调了医生意识和进一步研究的必要性.

科学领域:

微生物学微生物学
流行病学流行病学
遗传学遗传学是一个

背景情况:

超病毒性Klebsiella pneumoniae (hvKP) 是一种比经典的K. pneumoniae (cKP) 更有毒的病型,导致严重的致命疾病.
关于埃及hvKP的数据有限,特别是关于多药耐药 (MDR) 菌株的分子特征和克隆传播.

研究的目的:

调查hvKP的微生物学,遗传学和流行病学特征,导致呼吸器相关肺炎 (VAP).

主要方法:

来自阿苏特大学医院的59种K. pneumoniae VAP分离物的回顾性研究 (2017年11月至2019年1月).
现型耐药性测试,基因型分析 (囊K1/K2,病毒性基因c-rmpA,p-rmpA,iucA,kfu,iroB,iroN) 和耐药性基因检测 (blaNDM-1,blaCTX-M-3类,blaCTX-M-14类).
使用脉冲场凝电泳 (PFGE) 评估的克隆相关性.

主要成果:

HvKP构成了89.8%的分离物,其中约95%呈现广泛耐药 (XDR) 现型.
在hvKP中,iucA病毒性基因是最常见的 (98.1%). 抗性基因 blaCTX-M-3 样, blaNDM-1 和 blaCTX-M-14 样的高度流行.
PFGE揭示了15种脉型,表明hvKP的克隆传播,在不同ICU和不同时间发现了相同的菌株.

结论:

这项研究强调了埃及医院中XDR-hvKP菌株的流行率和克隆传播.
提高医生对hvKP诱导的VAP风险的认识至关重要.
建议进行进一步的流行病学研究,以监测和控制hvKP的传播.

关键词:

在VAP中使用VAP.cKPKP cKPKP是什么意思克隆相关性克隆相关性这就是HVKPKP.

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