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相关概念视频

Lung Capacity01:47

Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Gross Anatomy of the Lungs01:17

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The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Other Pulmonary Disorders01:17

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Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
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Gross Anatomy of the Liver01:17

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The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
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相关实验视频

Updated: Jul 27, 2025

Generation of Human 3D Lung Tissue Cultures 3D-LTCs for Disease Modeling
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Generation of Human 3D Lung Tissue Cultures 3D-LTCs for Disease Modeling

Published on: February 12, 2019

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肺 T 肺 T 肺

Vadim Malis1, Yoshimori Kassai2, Diana Vucevic1

  • 1Department of Radiology, University of California, San Diego, La Jolla, California, USA.

Magnetic resonance in medicine
|June 8, 2023
PubMed
概括
此摘要是机器生成的。

这项研究开发了一种新的3D超短回声时间 (UTE) 序列,用于准确的肺T2*映射. 改进的序列提高了T2*测量的准确性,为肺部疾病提供了潜在的见解.

关键词:
双指数模型是一个双指数模型.肺 肺 肺 肺 肺 肺 肺 肺 肺短T2和长T2的组成部分.超短 TE (UTE) 是指一个超短的TE.

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Lung Tumor Cell Recruitment Assay
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相关实验视频

Last Updated: Jul 27, 2025

Generation of Human 3D Lung Tissue Cultures 3D-LTCs for Disease Modeling
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科学领域:

  • 磁共振成像是一种磁共振成像技术.
  • 肺部医学 肺部医学
  • 生物物理学的生物物理.

背景情况:

  • 准确的T2*映射对于评估肺组织特征至关重要.
  • 传统的MRI序列通常与肺组织中发现的短T2*值相斗争.
  • 为了患者的舒适性和最大限度地减少运动工件,自由呼吸的获取是可取的.

研究的目的:

  • 开发和验证3D超短回声时间 (UTE) 序列,最小化回声时间间隔 (δTE).
  • 为了能够在自由呼吸期间准确地绘制T2*肺膜的地图.
  • 为了提高T2*量化在肺成像中的精度.

主要方法:

  • 实施了一种新的四回声UTE序列, δTE<0.5 ms.
  • 蒙特卡洛模拟,以优化回声的数量,以提高精度和扫描时间.
  • 用已知短T2*值 (<5毫秒) 进行验证的幻影研究.
  • 在3T对6名志愿者进行人体成像,使用单指数和双指数T2*配套模型.

主要成果:

  • 与标准的六回声UTE相比,模拟预测T2*精度在10回声下提高了2倍以上.
  • 幻影验证显示,与标准的六回声UTE相比,其准确性高达三倍.
  • 通过10个回声,成功地实现了自由呼吸的肺T2*映射.
  • 人类肺部的平均T2*值为1.62 ± 0.48 ms (单指数) 和1.00 ± 0.53 ms (双指数).

结论:

  • 一个具有优化 δTE 的新型 UTE 序列已成功实现并对短 T2* 幻体进行验证.
  • 该序列在自由呼吸的人类肺部成像中表现出有效性.
  • 在肺部成像中,双指数T2* 适配可能为患病的肺部状态提供宝贵的见解.