自抗原分析揭示了完全康复和长期COVID患者的共享后COVID签名
Aaron Bodansky1, Chung-Yu Wang2, Aditi Saxena2
1Division of Pediatric Critical Care Medicine, UCSF, San Francisco, California, USA.
JCI insight
|June 8, 2023
概括
在调查长期COVID时,这项研究发现SARS-CoV-2感染会改变自身抗体配置文件. 然而,没有特定的自身反应性抗体模式可以区分长期COVID和COVID-19后完全康复.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 后COVID条件 后COVID条件
背景情况:
- 长期COVID是一种在SARS-CoV-2感染后持续存在的健康问题,其原因尚不清楚.
- 自体抗体与COVID-19的严重程度和其他后病毒综合征有关,这表明在长期COVID中可能发挥作用.
研究的目的:
- 研究自身抗体在长期COVID病理生理学中的作用.
- 为了确定不同的自身抗体简介是否区分长期COVID患者和康复个体.
主要方法:
- 使用全蛋白体自身抗体检测技术 (PhIP-Seq).
- 分析了121名长期COVID患者,64名康复COVID-19患者和57名COVID前控制组的样本.
- 采用无偏见的,高通量自抗体分析.
主要成果:
- 鉴定出一种独特的自身反应特征,使SARS-CoV-2感染个体与未感染的对照区分开来.
- 在长期COVID患者和从COVID-19中完全康复者之间,没有发现自身反应性抗体模式的显著差异.
- 该研究发现,在SARS-CoV-2感染后,自身抗体概况发生了广泛的变化.
结论:
- 感染SARS-CoV-2导致自身抗体概况发生显著变化.
- 这项研究发现,自反应性抗体和长期COVID的发展之间没有直接关联.
- 需要进一步的研究来阐明长期COVID背后的机制.
相关概念视频
Autoimmune Disorders
529
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
529
Antigens Involved in Adaptive Immunity
565
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
565
Immunological Memory
695
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
695
Cross-reactivity
31.3K
Overview
31.3K
Myocarditis II: Clinical Features and Diagnostic Tests
12
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
12


