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植物amajoside通过抑制TRAF6/NF-κB轴来缓解急性败血症引起的器官功能障碍

Daili Feng¹, Ruying Guo¹, Wei Liao¹

¹Department of Emergency, Rongchang People's Hospital, Chongqing, China.

Pharmaceutical biology

|June 8, 2023

概括

植物amajoside (PMS) 在败血症模型中显著提高了生存率并减少了器官损伤. 它通过TRAF6/NF-κB通路抑制炎症和亡,从而为败血症提供了潜在的新疗法.

科学领域:

药理学药理学是指药理学的学科.
败血症病理生理学病理生理学
分子生物学分子生物学

背景情况:

植物amajoside (PMS) 具有不同的药理特性.
它在危及生命的败血症中的治疗潜力需要进一步调查.
败血症往往导致多器官功能障碍.

研究的目的:

为了调查Plantamajoside (PMS) 在败血症引起的器官功能障碍中的作用.
阐明PMS在败血症中的作用的潜在机制.

主要方法:

在C57BL/6小鼠中,通过结和穿孔 (CLP) 诱导了急性败血症.
小鼠接受了不同剂量的PMS治疗.
肺部,肝脏和心脏组织的病理和亡变化使用HE和TUNEL染色进行了评估.
量化了炎症标记物 (IL-6,TNF-α,IL-1β),损伤标记物和与亡相关的蛋白质.
分析了TRAF6 / NF-κB信号通路,使用西方模糊.

主要成果:

在败血症模型中,PMS的管理显著提高了生存率.
产前综合征治疗减少了肺部,肝脏和心脏的败血症中介损伤,由降低的MPO,BALF,AST,ALT,CK-MB和CK水平表明.
预孕前综合征有效抑制了亡并降低了IL-6,TNF-α和IL-1β的水平.
在PMS下降了TRAF6和p-NF-κB p65.5的表达.
过度表达TRAF6可以抵消PMS的保护作用.

结论:

植物amajoside (PMS) 通过调节TRAF6/NF-κB信号通路来缓解败血症引起的器官功能障碍.
产前综合征显示出作为一种新的治疗策略来管理与败血症相关的器官损伤的潜力.

关键词:

传统的中国医学是传统的中国医学.灭症 (apoptosis) 是一种死亡的过程.器官损伤器官损伤器官损伤系统性炎症系统性炎症

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