炎症标志物和心房动负担之间的关系的比较
Sefa Erdi Ömür1, Çağrı Zorlu1, Mustafa Yılmaz1
1Department of Cardiology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey.
Anatolian journal of cardiology
|June 8, 2023
概括
系统性免疫炎症指数 (SII),中性粒细胞-淋巴细胞比率和血小板-淋巴细胞比率等炎症标志物在心房动 (AF) 患者中升高. 这些标志物与AF负担相关,表明炎症在该疾病中起着关键作用.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
背景情况:
- 心房动 (AF) 是一种复杂的心律失常症,与不良的心血管结果有关.
- 炎症越来越被认为是AF病理生理学的重要因素.
- 评估炎症标志物有助于诊断和评估AF的严重程度.
研究的目的:
- 研究在被诊断为AF的患者中炎症生物标志物的作用.
- 为了比较发炎标志物水平在阳性和持续性AF之间,评估AF负担.
主要方法:
- 追溯研究包括来自心脏病门诊的752名患者.
- 患者被分为三个组:正常鼻节律 (n=140),神经系统性AF (n=145) 和永久性AF (n=206).
- 评估炎症标志物,包括系统性免疫炎症指数 (SII),中性粒细胞-淋巴细胞比率 (NLR) 和血小板-淋巴细胞比率 (PLR).
主要成果:
- 与正常鼻节律组相比,在阳性和永久性AF组中观察到SII,NLR和PLR的水平显著更高.
- 永久性AF显示较高的SII,NLR和PLR相比帕洛西斯马性AF.
- 在永久性和阴性AF组中,C-反应蛋白和SII之间发现了积极的相关性.
结论:
- 升高的SII,NLR和PLR表明炎症和AF负担之间存在强烈的关联.
- SII指数有效地反映了AF患者的炎症状况.
- 炎症生物标志物对于理解和管理心房动是有价值的.
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