降低风险的沙卵巢切除术对脂质决定因素,HbA1c和CRP的影响
R F M Vermeulen1,2, J L van Altena3, K N Gaarenstroom4
1Department of Gynecology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
概括
在绝经前妇女中,降低风险的卵管切除术 (RRSO) 导致HDL胆固醇和HbA1c显著增加,但心血管风险没有恶化. 绝经后的妇女在RRSO后没有显著的变化.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 心血管健康 心血管健康
背景情况:
- 建议BRCA1/2突变携带者在45岁之前接受降低风险的卵管切除术 (RRSO).
- RRSO对代谢和炎症标志物的影响需要进一步研究.
研究的目的:
- 评估RRSO对脂质谱,血红蛋白A1c (HbA1c) 和C反应蛋白 (CRP) 的影响.
- 为了比较这些变化在绝经前和绝经后的妇女之间.
主要方法:
- 研究了142名高风险女性 (92名绝经前,50名绝经后).
- 血清脂质 (LDL-C,HDL-C,总胆固醇,甘油三),HbA1c和CRP在RRSO之前和6周和7个月后被测量.
- 热冲也被评估.
主要成果:
- 绝经前的妇女在HDL胆固醇,胆固醇比率和HbA1c在正常范围内显著增加.
- 在RRSO后的绝经前妇女中,热显著增加.
- 绝经后的妇女没有经历任何显著的变化;然而,在7个月后,绝经前的妇女的LDL-C,甘油三,HbA1c和CRP较低,而绝经后的妇女的HDL更高.
结论:
- 在绝经前妇女中,RRSO会改变脂质样本和HbA1c,但这些变化仍在参考范围内.
- 在绝经后的女性中没有观察到显著的代谢或炎症变化.
- 在前7个月内,RRSO似乎不会增加心血管风险.
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