炎症脂肪组织:与肥胖相关的内皮损伤的治疗点
Wanlin Dai1,2, Ziqi Liu1,2, Shaojie Yang3
1Innovation Institute, China Medical University, Shenyang, 110122, Liaoning, China.
Endocrinology
|June 8, 2023
概括
与肥胖相关的炎症,特别是在周血管脂肪组织 (PVAT) 中,驱动心血管疾病 (CVD). 在PVAT中准免疫失调提供了对代谢和心血管健康的有前途的治疗策略.
科学领域:
- 心血管科学 心血管科学
- 免疫学 免疫学 免疫学
- 代谢性疾病研究研究
背景情况:
- 心血管疾病 (CVD) 是全球首要的死亡原因,与肥胖,内脏脂肪和异常周围血管脂肪组织 (PVAT) 密切相关.
- 脂肪组织内的炎症过程,包括免疫细胞两极分化和细胞因子失调,是代谢障碍和血管并发症的病原体的核心.
- 周血管脂肪组织 (PVAT) 在肥胖引起的血管损伤和内皮功能障碍中发挥着关键作用.
结论:
- 在PVAT中,肥胖引起的炎症对心血管疾病的发展有显著的贡献.
- 在PVAT中调节免疫细胞活性和细胞因子概况可能为代谢和心血管健康提供新的治疗策略.
- 对PVAT在肥胖中的作用进行进一步的研究对于开发针对心血管疾病的有效干预措施至关重要.
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