青春晚期的母乳养和ApoB:香港出生队列研究
C Mary Schooling1,2, Shiu Lun Au Yeung1, Man Ki Kwok3
1School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 1/F, Patrick Manson Building (North Wing), 7 Sassoon Road, Pokfulam, Hong Kong, China.
European journal of pediatrics
|June 8, 2023
概括
早期的纯母乳养与青春晚期的较低的阿波利波蛋白B (ApoB) 和非HDL胆固醇有关. 这一发现支持促进母乳养,以预防终身心血管疾病.
科学领域:
- 心血管疾病的研究研究.
- 儿童营养学 儿童营养学
- 公共卫生 公共卫生
背景情况:
- 阿波蛋白B (ApoB) 是一个关键的心血管疾病风险因素.
- 哺乳对晚年血脂状况的长期影响尚未得到充分证实.
- 关于母乳养的观察性研究容易引起社会经济上的混.
研究的目的:
- 调查母乳养与青少年脂质子部分,特别是ApoB和非高密度脂蛋白胆固醇 (非HDL-c) 之间的关联.
- 检查这些协会的整体和性别.
- 为了利用一个独特的环境,使母乳养的社会经济影响最小化.
主要方法:
- 利用了香港人口代表的"1997年儿童"出生队列.
- 用人线性回归调整为混因素 (社会经济地位,出生细节).
- 应用多重归算和反向概率权重来解释缺失的数据.
主要成果:
- 纯母乳养 (vs.从未) 与青春晚期显著降低ApoB水平 (-0.027 g/L) 和非HDL-c (-0.143 mmol/L) 相关.
- 这些关联在两性之间都是一致的.
- 这项研究包括3462名参与者,平均年龄为17.6岁.
结论:
- 母乳养可以为整个人口提供终身预防心血管疾病的保护.
- 促进母乳养是一种有价值的公共卫生策略,用于健康的开始和长期的心血管健康.
- 研究结果支持母乳养作为预防疾病的可修改暴露.
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