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脂肪细胞衍生的细胞外囊泡:弥合肥胖和瘤微环境之间的通信

Chuan Zhou^1,2, Yu-Qian Huang³, Ming-Xu Da^1,4

¹The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, People's Republic of China.

Discover oncology

|June 8, 2023

概括

肥胖通过脂肪细胞衍生的细胞外囊泡 (ADEVs) 推动癌症的进展. 这些囊泡在肥胖中发生变化,促进瘤生长和转移,突出显示ADEVs是潜在的癌症生物标志物和治疗点.

科学领域:

生物医学科学生物医学科学
在瘤学瘤学.
代谢研究研究代谢研究

背景情况:

肥胖是一个日益严重的全球健康危机,预计到2035年将影响超过40亿人.
肥胖引起的脂肪组织功能障碍有助于胰岛素抵抗和炎症.
脂肪细胞衍生的细胞外囊泡 (ADEVs) 在细胞间的通信中发挥着关键作用,特别是在脂肪组织和瘤微环境之间.

研究的目的:

阐明ADEVs在与肥胖相关的癌症进展中的作用.
探索ADEVs作为癌症诊断和预后生物标志物的潜力.
评估ADEVs作为新型抗瘤疗法的战略目标.

主要方法:

关于肥胖,脂肪组织,ADEV和癌症的最新文献的综述.
在肥胖与非肥胖状态下分析ADEV货物组成.
ADEV特征与癌症特征的相关性,例如扩散,血管新生,入侵,转移和免疫反应.

主要成果:

肥胖脂肪组织释放ADEVs与失调的货物,包括促炎性蛋白质,脂肪酸和瘤性微RNAs.
ADEVs涉及促进关键的癌症特征,包括瘤细胞的增殖,对亡的抵抗,血管生成,入侵和转移.
肥胖症中改变的ADEV概况与瘤微环境和全身炎症的显著改变有关.

结论:

ADEVs代表肥胖和癌症之间的关键联系,通过复杂的分子机制调解瘤进展.
作为肥胖相关癌症的诊断和预后生物标志物,ADEV具有显著的前景.
针对ADEVs是一个可行的策略,用于开发创新的抗瘤疗法,需要进一步的研究和临床翻译.

关键词:

脂肪细胞脂肪细胞癌症癌症癌症癌症细胞外囊泡中的细胞外囊泡.肥胖问题肥胖问题瘤微环境是一个微环境.

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