患有牛皮和没有牛皮的成年人体内 Carotid intima-media 厚度 - 基于ELSA-巴西队列基线数据的嵌套病例对照研究
William R Tebar1, Itamar de S Santos1, Vandrize Meneghini1
1Centro de Pesquisa Clínica e Epidemiológica (CPCE), Hospital Universitário, Universidade de São Paulo, Av. Lineu Prestes 2565, 3º andar, São Paulo, CEP: 05435-060, Brazil.
The international journal of cardiovascular imaging
|June 8, 2023
概括
在公务员的大型队列研究中,牛皮 (PSO) 与动脉内膜介质厚度 (cIMT) 没有关联. 需要进一步的纵向研究来探索cIMT进展和牛皮患者的疾病严重程度.
科学领域:
- 心脏病学 心脏病学
- 皮肤病学 皮肤病学
- 流行病学 流行病学
背景情况:
- 牛皮 (PSO) 是一种慢性炎症疾病,与心血管风险因素有着争论的关联.
- Carotid intima-media 厚度 (cIMT) 是亚临床动脉样硬化的标志物.
- 之前对PSO和cIMT的研究已经产生了不一致的结果,通常使用有限的患者群体.
研究的目的:
- 在一大批巴西公务员中调查牛皮和动脉内膜介质厚度 (cIMT) 之间的关联.
- 为了比较PSO个体的cIMT水平与匹配的对照和非PSO总体人口.
- 分析牛皮持续时间和cIMT之间的关系.
主要方法:
- 分析了来自ELSA-巴西研究的10,530名公务员队列.
- 牛皮病例 (n=162) 通过自我报告的诊断来确定.
- 倾向性得分匹配被用来创建一个没有公务员职责的对照组. cIMT被连续和明确地分析 (75百分点以上). 使用了多变量条件回归模型.
主要成果:
- 在PSO患者和总样本或匹配对照人群之间没有观察到平均cIMT的显著差异.
- 牛皮与cIMT的线性增量增加无关 (β = 0.003,p = 0.690与整体相比;β = 0.004,p = 0.633与对照相比).
- 在PSO患者中,没有发现超过75百分位的cIMT患病率增加 (OR = 1.06,p = 0.777与整体相比;OR = 1.19,p = 0.432与对照). 疾病持续时间也没有与cIMT相关 (β = 0.000,p = 0.627).
结论:
- 这项大型队列研究在巴西公务员中发现牛皮和动脉内膜介质厚度之间没有关联.
- 这些发现表明,轻度牛皮可能不是通过cIMT测量的亚临床动脉样硬化症的重要危险因素.
- 长度研究是有必要的,以评估cIMT的进展和牛皮严重程度对心血管风险的影响.
相关概念视频
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
16
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
16
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
19
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
19
01:26Atherosclerosis III: Management
15
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
15
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
38
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
38
01:30Atherosclerosis I: Introduction
13
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
13