艾滋病毒对COVID-19结果的影响:与年龄差异差异相匹配的倾向性得分分析
Siyuan Guo1,2, Jiajia Zhang1,2, Xueying Yang3,4
1Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
AIDS and behavior
|June 8, 2023
概括
艾滋病毒感染者 (PLWH) 面临更高的COVID-19死亡风险,特别是随着年龄的增长. 较低的免疫力 (CD4 < 200) 加剧了PLWH的严重COVID-19结果.
科学领域:
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 衰老和艾滋病毒感染是影响健康结果的重要因素.
- 了解艾滋病毒,衰老和COVID-19之间的相互作用对弱势群体至关重要.
研究的目的:
- 调查艾滋病毒和衰老对COVID-19结果的综合影响.
- 为了确定艾滋病毒对COVID-19严重性的影响是否与免疫状态 (CD4计数,病毒载量) 有所不同.
主要方法:
- 利用了来自国家COVID队列协作 (N3C) 的数据,包括超过240万名COVID-19患者.
- 采用多变量逻辑回归与精确和倾向得分匹配,以比较艾滋病毒感染者 (PLWH) 和没有艾滋病毒感染者之间的结果.
- 根据CD4计数和HIV病毒载量 (VL) 进行了子组分析.
主要成果:
- 与非PLWH相比,PLWH显示出更高的死亡风险,直到6年的年龄差异.
- 在所有匹配的队列中,PLWH始终面临住院风险升高的风险.
- 严重免疫功能低下的PLWH (CD4 <200细胞/毫米3) 持续增加死亡率和住院率.
- 艾滋病毒病毒载量≥200副本/毫升与住院治疗风险增加有关,不论年龄匹配.
结论:
- 在艾滋病毒的背景下,衰老显著增加了COVID-19死亡风险.
- 艾滋病毒感染独立地提高了COVID-19住院的风险,即使没有显著的年龄增长.
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