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一个逐步的准和抗菌策略由白细胞膜为基础的结合的寡合体纳米颗粒

Xiao Wei¹, Xiaoning Liu², Xinyue Liu¹

¹National-Local Joint Engineering Laboratory for Energy Conservation in Chemical Process Integration and Resources Utilization, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300131, P.R. China.

ACS applied bio materials

|June 8, 2023

概括

这项研究引入了一种新的仿生纳米粒子 (NPs@M-P) 用于针对细菌感染的治疗. 它有效地使用近红外光杀死阴性细菌,为抗生素耐药性提供了一个有前途的策略.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
传染性疾病传染性疾病

背景情况:

细菌感染给全球健康带来了重大挑战.
药物输送的限制和抗生素耐药性的增加使治疗复杂化.
新的治疗策略对于对抗细菌病原体至关重要.

研究的目的:

设计和评估一个有针对性的,仿生纳米粒子系统,用于增强抗菌疗法.
调查近红外触发热和反应性氧物种 (ROS) 生成对杀死细菌的有效性.
开发一种多模式的方法来克服细菌耐药性并改善治疗结果.

主要方法:

使用白细胞膜和Polymyxin B (PMB) 制造一个逐步向的仿生纳米粒子 (NPs@M-P).
证明了格拉姆阴性细菌的向性和纳米颗粒的炎症倾向.
在低功率近红外 (NIR) 光照射下评估抗菌活性,评估热量和ROS产量.

主要成果:

通过白细胞膜和PMB,NP@M-P成功地准了阴性细菌.
近红外辐射诱导了显著的热量和ROS产生的纳米粒子.
在NIR触发下,可以有效地杀死阴性细菌,并显示出强大的抗菌作用.

结论:

开发的仿生纳米颗粒为打击格兰氏阴性细菌感染提供了有针对性和有效的策略.
这种多式疗法,结合了向治疗和NIR触发的作用,显示了克服抗生素耐药性的潜力.
NPs@M-P系统在开发新型抗菌疗法方面呈现出有前途的进展.

关键词:

格拉姆阴性细菌是一种细菌.它是一种抗菌药物,具有抗菌作用.生物模拟纳米粒子生物模拟纳米粒子接近红外光的近红外光.一步一步地定位目标

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