基线情感症状缓和高强度THC和CBD大麻缩剂的急性主观影响
Renée Martin-Willett1, Carillon J Skrzynski1, Hollis C Karoly2
1Department of Psychology and Neuroscience, University of Colorado Boulder.
Experimental and clinical psychopharmacology
|June 8, 2023
概括
高效的大麻缩物,如THC和CBD,根据先前存在的抑郁症不同地影响情绪. THC可能会增加积极的心情,而CBD可以减少消极的心情,但THC可能会使某些用户的情绪恶化.
科学领域:
- 心理药理学 心理药理学
- 大麻研究 大麻研究
- 心理健康 心理健康
背景情况:
- 含有delta-9-tetrahydrocannabinol (THC) 和cannabidiol (CBD) 的高强度大麻缩剂越来越普遍.
- 它们对情绪和中毒的急性影响,特别是与先前存在的情感症状相关的影响,尚不清楚.
研究的目的:
- 为了研究基线情感症状 (焦虑,抑郁) 如何影响急性情绪和自然使用THC主导与CBD主导大麻缩物中毒.
- 探索基线影响对大麻缩剂消费主观体验的调节作用.
主要方法:
- 54名大麻使用者被分配使用THC主导或CBD主导的缩物.
- 参与者在基线完成评估,并在使用产品后立即和1小时完成评估.
- 统计模型检查了产品状况,时间和基线情绪和中毒情绪情绪症状之间的相互作用.
主要成果:
- 基线抑郁症和产品状况之间的相互作用影响了积极的心情;较高的抑郁症与THC占主导地位的使用与更大的积极心情有关.
- 负面情绪在CBD占主导地位的使用下降,但在较高抑郁水平的THC占主导地位时增加.
- 与CBD占主导地位的组相比,THC占主导地位的组在使用后报告了更高的中毒水平.
结论:
- 基线情感症状显著缓解大麻缩剂的急性主观影响.
- 情绪状态的个体差异可以影响THC和CBD的感知影响,这表明大麻使用的个性化方法.
- 这项研究强调了大麻化学型,使用者影响和急性药物反应之间的复杂相互作用.
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