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艾滋病毒暴露前预防的启动,持久性和坚持在怀孕期间通过产后期
Jillian Pintye1, John Kinuthia1,2, Felix Abuna2
1University of Washington, Seattle, Washington, USA.
AIDS (London, England)
|June 8, 2023
概括
在孕妇中评估了暴露前预防 (PrEP) 的启动和持续时间. 虽然超过一半的产后持续,但坚持下降,突出显示需要产后支持.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗逆转录病毒治疗对于预防艾滋病毒至关重要.
- 暴露前预防 (PrEP) 是预防艾滋病毒的一个关键策略.
- 在孕妇群体中评估PrEP对于母婴健康至关重要.
研究的目的:
- 评估孕妇在暴露前预防 (PrEP) 开始,持续和坚持的情况.
- 在干血斑点 (DBS) 中测量使用特诺福维尔二酸盐 (TFV-DP) 度的粘附性.
- 为了确定影响孕妇在怀孕期间和怀孕后使用PrEP的因素.
主要方法:
- 来自PrIMA研究 (NCT03070600) 数据的前性分析.
- 参与者在妊娠第二季度接受了PrEP,并在产后9个月内进行了跟踪.
- 自我报告的PrEP使用和TFV-DP量化DBS在怀孕期间每月间隔评估,6周,6个月,9个月产后.
主要成果:
- 在2949名参与者中,有14%的参与者在怀孕期间启动了PrEP,HIV风险因素较高的人群中,这一比例更高.
- 58%的PrEP发起者在产后9个月内持续使用; 54%的人报告没有错过剂量.
- 在50%的持续使用者的样本中发现了可量化的TFV-DP,在怀孕期间比分娩后更高 (aRR=1.90).
- 拥有艾滋病毒感染者的伴侣是PrEP启动,坚持和坚持的最强预测因素.
结论:
- 尽管超过一半的发起者继续使用,但PrEP的持久性和坚持性在分娩后下降.
- 干预措施应侧重于提高对伴侣艾滋病毒状况的了解.
- 在产后期间保持PrEP的坚持对于持续的艾滋病毒预防至关重要.
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