由海洋衍生的真菌产生的多基化物和化物衍生的代谢物,
Marcelo R de Amorim1, Camila de S Barbosa2, Tiago A Paz3
1Instituto de Química de São Carlos, Universidade de São Paulo, CEP 13560-970, São Carlos, SP, Brazil.
Journal of natural products
|June 8, 2023
概括
海洋真菌Peroneutypa sp. 在海中生长 M16产生了七种新的多基化物和化物代谢产物. 化合物5对杆菌有中度的抗菌活性,有助于药物发现研究.
科学领域:
- 海洋天然产品 化学 化学
- 菌类代谢学 菌类代谢学
- 药用化学 医学化学
背景情况:
- 海洋衍生真菌是结构多样化的二次代谢物的丰富来源.
- 佩罗尼乌提帕物种是已知的生物活性化合物的生产者.
- 研究新代谢物对于识别新的治疗线索至关重要.
研究的目的:
- 从海洋真菌Peroneutypa sp.中分离和描述新的代谢物. M16.M16.M16.M16.M16.M16.M16.M16.M16.M16.M16.M16.M16.M16.M16.M16.M.
- 为了评估分离的化合物的抗等离体活性.
- 为了确定新化学实体的绝对配置.
主要方法:
- 用生物测试指导的真菌提取物的分化.
- 使用综合光谱分析 (NMR,MS) 阐明结构.
- 通过实验和计算的电子循环二元化 (ECD) 数据来确定绝对配置.
主要成果:
- 除了已知的化合物 (3,9-13),还分离了七种新的聚基化物和化物衍生代谢物 (1,2,4-8),以及已知的化合物 (3,9-13).
- 通过详细的光谱分析证实了新化合物的结构.
- 化合物5对对素敏感和耐药的Plasmodium falciparum菌株表现出适度的抗菌活性.
结论:
- 在海洋的真菌Peroneutypa sp. . M16产生了新型的多基化物和化物代谢产物.
- 化合物5代表了开发新抗疟疾药物的潜在支架.
- 需要进一步研究化合物5的抗等离子体机制.
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