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在手术前使用低分子量肝素对脊髓转移患者进行手术前的深静脉血栓形成是安全的吗? 一个前性研究研究
Yun-Qi Jiang1, Ling-Yan Wang2, Shun-Qi Hu1
1Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, PR China.
概括
低分子量肝素 (LMWH) 对手术前深静脉血栓瘤 (DVT) 脊髓转移患者是安全的. 这种抗凝剂没有增加出血并发症,这表明它在这个高危人群中具有潜在的益处.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 整形外科 整形外科 整形外科
背景情况:
- 脊髓转移患者经历解压与固定面临深静脉血栓形成 (DVT) 的高风险.
- 在这些患者手术前的DVT需要仔细考虑抗凝剂的风险与益处,特别是出血并发症.
研究的目的:
- 为了前性地评估手术前的DVT在脊髓转移患者的安全性和患病率,这些患者经历了固定式减压.
- 评估给患有手术前 DVT 的患者服用抗凝血剂,特别是低分子量肝素 (LMWH) 的安全性.
主要方法:
- 在脊髓转移患者中对DVT患病率的前性调查.
- 对抗凝血剂组 (手术前 DVT 的LMWH) 与非抗凝血剂组进行比较.
- 收集和分析患者数据,临床参数,血液检查和出血并发症.
主要成果:
- 在研究人群中,手术前DVT的患病率为8.0%.
- 在任何患者中都没有发生肺血栓塞栓症.
- 在抗凝固剂和非抗凝固剂组之间没有观察到血液损失,输血需求或严重出血的显著差异. 在非抗凝剂组中发生了轻微的出血并发症 (血瘤,切口出血).
结论:
- 皮下LMWH给药似乎是安全的脊髓转移患者与手术前的DVT.
- 需要进一步的随机对照试验来证实术后预防性抗凝剂在该患者队列中的疗效和安全性.
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