乳腺癌的结果 - 种族是否重要?
1Division of Medical Oncology, National Cancer Centre Singapore, Singapore; Oncology Academic Clinical Programme, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore.
ESMO open
|June 8, 2023
概括
遗传血统和生活方式因素显著影响乳腺癌 (BC) 存活率差异. 了解这些复杂的生物和环境影响对于改善不同人群的结果至关重要.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 乳腺癌 (BC) 存活率的种族差异已被记录,但往往依赖于不准确的自我报告种族.
- 基因组数据和遗传祖先量化提供了一个更准确的方法来了解不同种群中的混合物.
- 现有的研究主要比较非洲裔美国人和非西班牙裔白人,限制了更广泛的种族比较.
研究的目的:
- 审查最近关于宿主和瘤生物学的发现,这些发现有助于BC生存差异.
- 探索环境,生活方式和社会经济因素在BC结果中的作用.
- 突出在不同人群中进行多主题研究的必要性,以解决种族差异.
主要方法:
- 关于乳腺癌存活率的近期大型研究的综述.
- 对遗传祖先数据的分析,以推断复杂的种族混合.
- 检查宿主/瘤生物学,环境,生活方式和社会经济因素.
主要成果:
- 社会经济因素,如较低的癌症素养,有助于晚期呈现和较差的治疗坚持.
- 生活方式因素 (饮食,肥胖,不活动) 和较高的全静电负荷与积极的BC特征相关.
- 生殖系遗传学和表观遗传重编程可能会影响BC亚型和跨种族的结果.
结论:
- 在BC结果的种族差异是由遗传祖先,宿主/瘤生物学和社会经济/环境因素的复杂相互作用驱动的.
- 在多种不同人群中进行进一步的多学科研究对于进行可靠的比较和了解潜在机制至关重要.
- 需要一种整体的方法,将生物见解与改善医疗保健接入相结合,以消除BC生存差异.
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