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患有生长激素缺乏症的儿童和青少年的血管功能和内膜厚度:从前性病例对照研究的结果

Nicola Improda^1,2, Cristina Moracas³, Giuseppina Mattace Raso⁴

¹Paediatric Endocrinology Unit, Department of Translational Medical Sciences, "Federico II" University, Naples, Italy.

Hormone research in paediatrics

|June 8, 2023

概括

患有生长激素缺乏症 (GHD) 的儿童表现出动脉样硬化的早期迹象,包括内皮功能障碍和改变的脂质样本. 增长激素 (GH) 治疗有效地逆转这些标记物,改善血管健康.

科学领域:

儿科内分泌学儿科内分泌学
心血管研究研究心血管研究
代谢障碍代谢障碍代谢障碍

背景情况:

生长激素缺乏 (GHD) 与潜在的心血管问题有关.
现有的关于GHD儿童血管健康的数据有限且不一致.
这项研究研究了GHD对内皮功能和血管结构的影响.

研究的目的:

在患有GHD的儿童中评估内皮功能和亲密介质厚度 (IMT).
确定生长激素 (GH) 治疗对这些血管参数的影响.
在GHD儿科患者中识别早期动脉样硬化标志物.

主要方法:

对比24名GHD儿童与24名年龄,性别和BMI匹配的对照.
测量了人体测量,脂质概况,不对称的二甲基氨酸 (ADMA),臂流介导扩张 (FMD) 和大脑动脉内膜介质厚度 (cIMT,iIMT).
在GH治疗12个月后重新评估了GHD儿童.

主要成果:

在基线时,GHD儿童的胆固醇,LDL,动脉动脉生成指数 (AI),ADMA和腰与身高比率 (WHtR) 较高.
GH治疗减少了WHtR,胆固醇,LDL,AI和ADMA.
内皮功能 (FMD) 在GHD儿童中受损,但在GH治疗后得到改善;IMT在治疗后略有减少.

结论:

儿童的GHD与内皮功能障碍和早期动脉样硬化指标有关.
这些包括内脏脂肪和脂质不良.
增长激素治疗有效地恢复了血管功能,并改善了这些标记物.

关键词:

动脉样硬化是一种动脉样硬化.心脏代谢风险心脏代谢风险内皮质功能障碍内皮质功能障碍生长激素缺乏,生长激素缺乏.

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