对细菌和病毒感染的子宫内膜反应:一个范围审查
Christina V Lindsay1, Julie A Potter1, Alyssa A Grimshaw2
1Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
Human reproduction update
|June 8, 2023
概括
本综述总结了子宫内膜如何应对细菌和病毒感染,确定知识差距和新的研究模式,以更好地了解子宫健康和生育能力.
科学领域:
- 生殖免疫学 生殖免疫学
- 传染性疾病 传染性疾病
- 细胞生物学 细胞生物学
背景情况:
- 子宫内膜对于怀孕至关重要,但子宫内感染可能导致植入失败和流产.
- 了解子宫内膜对病原体的免疫反应至关重要,但仍未得到充分研究.
- 特定物种的研究阻碍了理解人类子宫内膜免疫力的进展.
研究的目的:
- 系统地审查关于子宫内膜对细菌和病毒的先天免疫反应的人类和动物研究.
- 确定参与子宫内膜免疫反应的信号机制.
- 确定知识差距,并为未来的研究方向提供信息.
主要方法:
- 搜索了多个数据库 (Cochrane,Embase,Medline,PubMed,Scopus,Web of Science) 截至 2022 年 3 月.
- 包括对人类和实验室动物对细菌和病毒感染的子宫内膜反应的研究,不包括养物种.
- 从最初识别的42,000多项研究中评估了76项研究.
主要成果:
- 大多数研究都集中在大肠杆菌和淋巴结核菌上,对艾滋病毒,寨卡病毒和疹病毒等病毒的研究有限.
- 研究使用了体外和体内模型来检查细胞因子/化学因子的产生和先天免疫信号.
- 确定了对各种病原体的子宫内膜反应的理解方面的差距,并突出了新兴的有机体和共同培养模型.
结论:
- 本综述对目前关于子宫内膜感染免疫反应的知识进行了基准评估.
- 强调最近有机体和共同培养系统的进展,以提供更相关的研究模型.
- 强调需要进一步研究以阐明子宫功能上的机制和下游影响.
相关概念视频
01:29Immune Response Against Viral Pathogens
833
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
833
01:24Disorders of the Female Reproductive System
421
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
421
01:26Factors Affecting the Risk of Infection
12.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.0K