的全量测法
Tanvi Kale1, Dhruv Khatri1, Chaitanya A Athale1
1Division of Biology, IISER Pune, Dr Homi Bhabha Road, Pashan, Pune 411008, India.
Physical biology
|June 8, 2023
概括
细菌细胞表面积 (SA) 和体积 (V) 的缩放与几何定律 (SA ~ V2/3) 偏离,当考虑种群变异性和细胞分裂动态时. 细胞变异性增加,而不仅仅是平均大小,显著影响SA-V缩放.
科学领域:
- 微生物学 微生物学
- 细胞生物学 细胞生物学
- 生物物理学的生物物理.
背景情况:
- 细胞大小和形状的调节对细菌生长至关重要.
- 大肠杆菌是研究细胞缩放的一个模型生物.
- 之前的研究重点是现象学和缩放的分子机制.
研究的目的:
- 调查人口统计和细胞分裂动态对细菌表面积-体积 (SA-V) 缩放的影响.
- 为了确定SA-V缩放是否在不同的条件下遵守几何定律 (SA ~ V2/3).
主要方法:
- 对大肠杆菌的显微镜和图像分析.
- 统计模拟用于模拟细胞大小分布和可变性.
- 细胞周期时间序列的虚拟同步以分析相位特定缩放.
主要成果:
- 中日志阶段细胞表现出接近几何定律的SA-V缩放 (指数2/3).
- 丝状细胞和增加的生长率导致更高的缩放指数 (>2/3).
- 种群变异性,特别是细胞长度的标准偏差,显著影响SA-V缩放,往往超过几何预测.
结论:
- 细菌SA-V缩放受人口统计和细胞分裂动态的影响,而不仅仅是几何规律.
- 细胞变异性在SA~V2/3缩放的偏差中起着至关重要的作用.
- 未来的研究必须纳入人口异质性和细胞周期进展,以准确地估计SA-V缩放.
相关概念视频
Deformation of Member under Multiple Loadings
197
When a rod is made of different materials or has various cross-sections, it must be divided into parts that meet the necessary conditions for determining the deformation. These parts are each characterized by their internal force, cross-sectional area, length, and modulus of elasticity. These parameters are then used to compute the deformation of the entire rod.
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...
197
Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity
301
Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
301
Generalized Hooke's Law
1.1K
The generalized Hooke's Law is a broadened version of Hooke's Law, which extends to all types of stress and in every direction. Consider an isotropic material shaped into a cube subjected to multiaxial loading. In this scenario, normal stresses are exerted along the three coordinate axes. As a result of these stresses, the cubic shape deforms into a rectangular parallelepiped. Despite this deformation, the new shape maintains equal sides, and there is a normal strain in the direction of the...
1.1K
Temperature Dependent Deformation
174
In a nonhomogeneous rod made up of steel and brass, restrained at both ends and subjected to a temperature change, several steps are involved in calculating the stress and compressive load. Due to the problem's static indeterminacy, one end support is disconnected, allowing the rod to experience the temperature change freely. Next, an unknown force is applied at the free end, triggering deformations in the rod's steel and brass portions. These deformations are then calculated and added...
174
Bending of Members Made of Several Materials
232
In analyzing a structural member composed of two different materials with identical cross-sectional areas, it is crucial to understand how their distinct elastic properties affect the member's response under load. The analysis involves assessing stress and strain distributions using the transformed section concept, which accounts for variations in material properties.
Hooke's Law determines stress in each material, stating that stress is proportional to strain but varies due to each...
Hooke's Law determines stress in each material, stating that stress is proportional to strain but varies due to each...
232
Normal Strain under Axial Loading
586
Normal strain under axial loading is an important concept in the field of mechanics of materials. Axial loading implies the application of a force along the axis of a material, like a column or bar. This force can either compress or stretch the material. In the context of axial loading, normal strain is the deformation experienced by the material in the direction of the loading force. It's calculated as the change in length divided by the original length of the material. This unitless ratio...
586


