胰岛素类生长因子受体 / mTOR信号提升全球翻译以加速斑马鱼翅膀再生外生长
Victor M Lewis1, Heather K Le Bleu2, Astra L Henner1
1Institute of Molecular Biology, University of Oregon, 273 Onyx Bridge, 1318 Franklin Blvd, Eugene, OR, 97403-1229, USA.
Developmental biology
|June 8, 2023
概括
斑马鱼的翅膀再生依赖于协调纤维细胞和骨质细胞分化的骨干细胞. 胰岛素生长因子受体 (IGFR) /机械标的拉帕氨酸激酶 (mTOR) 信号调节蛋白质的生产,控制的再生速度.
科学领域:
- 再生生物学 再生生物学
- 分子生物学分子生物学
- 斑马鱼模型 斑马鱼模型
背景情况:
- 斑马鱼的翅膀通过囊胚形成再生,涉及无差异化骨质母细胞和激活的纤维母细胞.
- 了解推动协调再生的细胞和分子机制至关重要.
研究的目的:
- 用单细胞转录组学来表征的再生生长.
- 为了确定协调细胞在再生过程中的行为分子通路.
主要方法:
- 斑马鱼再生的单细胞RNA测序.
- 计算分析以识别细胞谱系和标记.
- 在体内追踪血统和药物抑制研究.
主要成果:
- 确定了再生系的独特细胞群,包括纤维细胞和骨质细胞.
- 发现了Blastemal mesenchyme中蛋白质的产量增加,这取决于IGFR/mTOR信号传递.
- 显示的IGFR/mTOR信号加速骨质母细胞分化并调节的再生速度.
结论:
- 远端叶芽细胞介质补充纤维细胞,通过IGFR/mTOR信号调节蛋白质合成.
- IGFR/mTOR 作为一个静脉静止剂,协调细胞分化和再生速度.
相关概念视频
mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
PI3K/mTOR/AKT Signaling Pathway
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a rapamycin-insensitive companion...
mTOR Signaling and Cancer Progression
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...


