中性粒细胞在与酒精有关的肝炎中的作用
Reenam S Khan1, Patricia F Lalor1, Mark Thursz2
1Centre for Liver and Gastrointestinal Research, Institute of Immunology and Inflammation, and National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, The Medical School, University of Birmingham, Birmingham, B15 2TT, UK.
Journal of hepatology
|June 8, 2023
概括
中性粒细胞在与酒精有关的肝炎 (AH) 中起着关键作用,这是严重的肝脏疾病. 了解中性粒细胞功能和子集为AH提供了潜在的治疗点,改善了患者的治疗结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 与酒精有关的肝病 (ARLD) 是死亡的一个重要原因,与酒精相关的肝炎 (AH) 构成严重的临床和经济负担.
- 严重的AH与高的短期死亡率有关,通常是由于感染,其特点是肝脏和血液循环中中性粒细胞活性增加.
研究的目的:
- 审查有关中性粒细胞在与酒精有关的肝炎 (AH) 中多方面的作用的文献.
- 阐明中性粒细胞招募机制,改变的抗菌功能,以及不同中性粒细胞子集在AH中的重要性.
- 探索潜在的治疗策略,以中性粒细胞功能为治疗AH的目标.
主要方法:
- 文献综述侧重于中性粒细胞参与与酒精有关的肝炎 (AH).
- 分析中性粒细胞的招募,抗菌功能 (化学反应,细胞化,氧化突发,NETosis) 和子集变异 (高密度与低密度).
- 检查中性粒细胞对巨细胞两极分化和肝脏再生的影响.
主要成果:
- 在AH中,中性粒细胞被招募到炎症肝脏中,具有改变的抗菌功能.
- 有证据表明,在AH中存在不同的中性粒细胞子集 (高密度和低密度).
- 中性粒细胞通过与巨细胞的相互作用,可能有助于AH中的损伤解决和肝脏再生.
结论:
- 中性粒细胞的动态和功能是与酒精相关的肝炎 (AH) 的发病和潜在解决的核心.
- 针对中性粒细胞的招募或功能,可能通过解决肠道失调或增强miR-223来解决,为AH提供了一个有希望的治疗途径.
- 开发可靠的中性粒细胞子集标记物和准确的动物模型对于推进AH的翻译研究至关重要.
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