相关实验视频
Updated: Jul 27, 2025
10:43
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
3.4K
探索细胞竞争,以预防和治疗食道状细胞癌
Kristen Knapp1, Vincent Verchio1, Olivia Coburn-Flynn1
1Department of Surgery, Cooper University Hospital, Camden, NJ 08103, USA.
Biochemical pharmacology
|June 8, 2023
概括
细胞竞争,即具有更高适应性的细胞超越其他细胞,推动食道状细胞癌 (ESCC) 的发展. 操纵这个过程为ESCC预防和治疗提供了新的治疗策略.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 癌症基因组学 癌症基因组学
背景情况:
- 食道状细胞癌 (ESCC) 是由于食道上皮质中累积的遗传和表观遗传变化引起的.
- 与癌症相关的突变在正常或癌前细胞中发现,但只有很少的突变进展到ESCC,这表明细胞竞争的作用.
- ESCC瘤是异质的,癌细胞以动态的方式相互作用并相互竞争,特别是在治疗期间.
研究的目的:
- 探索细胞竞争在ESCC的发展,预防和治疗中的作用.
- 检查细胞竞争如何影响突变克隆的进展到临床癌症.
- 确定细胞竞争作为ESCC的潜在治疗点.
主要方法:
- 关于癌症细胞竞争现有文献的综述.
- 在ESCC期间参与细胞竞争的关键途径和基因 (NRF2,NOTCH,TP53) 的分析.
- 讨论瘤和治疗期间癌细胞竞争的动态性质.
主要成果:
- 细胞竞争是ESCC致癌的关键机制,在这种情况下",超级竞争者"突变细胞逃避正常细胞调节.
- 在ESCC瘤中的不同克隆的竞争能力是动态的,并影响治疗反应.
- 了解细胞竞争动态对于开发有效的癌症疗法至关重要.
结论:
- 细胞竞争在ESCC启动,进展和对治疗的反应中起着重要作用.
- 向细胞竞争为ESCC的新临床转化提供了一个有希望的途径.
- 操纵细胞竞争可以增强ESCC预防和治疗策略.
相关概念视频
01:21Barrett Esophagus-II: Clinical Manifestations and Management
218
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
218
01:21Barrett Esophagus-I: Introduction
139
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
139
02:38Mitogens and the Cell Cycle
6.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
01:26Esophageal Strictures-II: Clinical Features and Management
114
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
114
02:49Cancer Therapies
7.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K