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Updated: Jul 27, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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克里索提尼布通过阻断膜上皮细胞中的自流来诱导肺毒性

Yuanteng Zhang1, Zizheng Gao2, Zezheng Pan2

  • 1Center for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China; Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.

Biochemical pharmacology
|June 8, 2023
PubMed
概括

克里佐替尼 (crizotinib) 通过阻断膜细胞的自,导致炎症而导致肺损伤. 甲福明可以通过恢复自和减少纤维化来保护肺功能.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.自自是一种自的过程.克里佐丁尼布 (crizotinib) 是一种可以甲胺是一种甲胺.肺部毒性 肺部毒性 肺部毒性

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