微生物伊塔康酸生物生产向可持续发展:洞察力,挑战和前景
Priskila Adjani Diankristanti1, I-Son Ng1
1Department of Chemical Engineering, National Cheng Kung University, Tainan 701, Taiwan.
Bioresource technology
|June 8, 2023
概括
微生物生物制造提供了一种可持续的生产价值化学品 - - 伊塔康酸 (IA) 的途径. 本综述详细介绍了使用自然微生物和人工微生物制造IA的进展,并强调了未来的战略.
科学领域:
- 生物技术是生物技术.
- 工业微生物学 工业微生物学
- 合成生物学 合成生物学
背景情况:
- 微生物生物制造是生产高价值低碳化学品的关键策略.
- 伊塔康酸 (IA) 是一种具有广泛应用的多功能平台化学物质,被确定为生物质的最高附加值产品.
- 自然生产发生在像Aspergillus和Ustilago这样的真菌中,通过特定的酶途径.
研究的目的:
- 为了提供一个全面的回顾,最近的进步在伊塔科尼酸 (IA) 生物生产.
- 总结IA合成的原生微生物宿主和人工微生物宿主方面的进展.
- 讨论当前的挑战和可持续IA生产的未来战略.
主要方法:
- 对本地和转基因宿主 (例如,大肠杆菌,谷氨酸菌,大肠杆菌,Yarrowia lipolytica) 的IA产生的文献进行审查.
- 总结体内和体外方法来提高IA产量.
- 分析组合战术和最近的研究成果.
主要成果:
- 在工程非本地微生物宿主中取得了重大进展,以实现高效的IA生产.
- 已使用各种基因工程策略和发酵方法来提高IA标题,速率和产量.
- 在体内和体外方法,以及组合策略,显示优化IA生物合成的希望.
结论:
- 工程微生物系统为可再生AI生产提供了可行和可持续的替代方案.
- 通过创新策略应对当前的挑战,对于推进IA生物制造至关重要.
- 优化的IA生产通过提供生物化学替代品,为可持续发展目标 (SDGs) 作出贡献.
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