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在癌症中制定免疫排除的定义:经过修改的德尔菲研讨会的结果
Guy Travis Clifton1, Mace Rothenberg2, Paolo Antonio Ascierto3
1Parthenon Therapeutics, Boston, Massachusetts, USA Travis@parthenontx.com.
Journal for immunotherapy of cancer
|June 8, 2023
概括
检查点抑制剂在癌症治疗中表现有前途,但许多患者没有受益. 专家们定义了"免疫排除"瘤,这是免疫疗法耐药性的关键因素,以改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 免疫检查点抑制剂 (ICI) 通过调节瘤微环境 (TME) 是有效的癌症治疗方法.
- 然而,只有少数患者对ICI有反应,而TME特征预测了治疗灵敏度.
- 存在三种T细胞透模式:免疫沙漠,免疫活性和免疫排除,后者定义不佳,与糟糕的结果有关.
研究的目的:
- 建立"免疫排除"TME表型的共识定义.
- 澄清免疫排斥在抵抗免疫检查点抑制剂中的作用.
- 确定针对免疫排除机制的研究重点.
主要方法:
- 一个经过三轮修改的Delphi方法,涉及16名多学科的癌症专家.
- 最初的开放式问卷,随后进行了面对面的讨论和修订的陈述.
- 最后一个达成共识的问卷,完成率为100%.
主要成果:
- 为免疫排除制定了一个实际的,临床上相关的共识定义.
- 关于免疫排斥在检查点抑制剂耐药性中的作用达成共识.
- 确定了解决免疫排斥问题的五个关键研究重点.
结论:
- 德尔菲过程推进了对各种癌症类型免疫排斥的理解和定义.
- 这项工作提供了研究免疫排斥机制和开发向治疗的工具.
- 更好地理解和准免疫排除可能会增强患者对免疫治疗的反应.
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