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在多发性硬化症中伴随性抑郁症的多元性
Kaarina Kowalec1, Kathryn C Fitzgerald2, Amber Salter2
1From the College of Pharmacy (K.K.), Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Department of Medical Epidemiology & Biostatistics (K.K., A.H., S.H., Y.L.), Karolinska Institutet, Stockholm, Sweden; Department of Neurology (K.C.F.), Johns Hopkins School of Medicine, Baltimore, MD; Department of Neurology (A.S.), UT Southwestern, Dallas, TX; Department of Internal Medicine (C.D., C.N.B., R.A.M.), Department of Psychiatry (J.B.), and Department of Community Health Sciences (J.B., R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Department of Biostatistics (G.R.C., A.P., H.K.T.), University of Alabama at Birmingham; Department of Clinical Health Psychology (L.A.G.), and Department of Rheumatology (C.A.H.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Icahn School of Medicine at Mount Sinai (F.L.), New York, NY; Department of Clinical Neuroscience (K.A.M.), Karolinska Institutet, Stockholm, Sweden; Department of Community Health Sciences (S.B.P.), Cumming School of Medicine, University of Calgary, Alberta, Canada; and Department of Neurology (J.S.W.), McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston. kaarina.kowalec@gmail.com.
较高的抑郁多原性评分 (PGS) 会增加多发性硬化症 (MS) 患者患抑郁症的风险. 这种遗传风险是相似的,无论抑郁症是否与MS或主要疾病共患.
科学领域:
- 神经遗传学 神经遗传学
- 精神病学流行病学 精神病学流行病学
- 多发性硬化症研究研究
背景情况:
- 抑郁症是多发性硬化症 (MS) 的常见并发症,经常加速残疾进展.
- 在MS中抑郁症的确切原因尚未完全理解,需要新的识别策略.
- 现有的抑郁症遗传研究可能不能准确地反映其在MS中作为伴随性疾病的发生.
研究的目的:
- 调查抑郁症的多基因分数 (PGS) 与MS患者共发性抑郁症风险之间的关联.
- 为了确定抑郁症的遗传倾向是否与MS发生时不同,而不是当它是主要疾病时.
主要方法:
- 利用了来自加拿大,英国生物银行和美国的106,682名欧洲遗传祖先的个人数据.
- 将参与者分类为病例 (患有抑郁症的MS),并将其与对照组 (没有抑郁症的MS,没有免疫疾病的抑郁症,健康个体) 进行比较.
- 采用了三种抑郁症定义:临床诊断,自我报告诊断和抑郁症状,使用回归分析PGS关联.
主要成果:
- 与MS但没有抑郁症 (OR范围1.29-1.38) 和健康对照 (OR范围1.49-1.53) 相比,MS和抑郁症患者的抑郁PGS显著更高.
- 高度抑郁症PGS和MS抑郁症之间的关联在不同的抑郁症定义和性别分层中是一致的.
- 身体质量指数 (BMI) 的多基因分数与抑郁症状相关 (p ≤0.001),而抑郁PGS在并发性抑郁和原发性抑郁之间没有显著差异.
结论:
- 对抑郁症的高度遗传倾向与患MS的欧洲血统个体中抑郁症的可能性增加30%-40%有关.
- 在MS中抑郁症的遗传基础似乎与初级抑郁症的遗传基础相似,这表明共同的遗传因素.
- 这项研究支持多基因评分对评估MS群体精神疾病风险的潜在实用性,并保证在多样化的祖先中进行进一步调查.
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