细胞块在尿细胞学中的实用性和性能:在三个教学医院的经验
Nancy Y Greenland1,2, Nikka Khorsandi1, Yue Peng1,2
1Department of Anatomic Pathology, University of California, San Francisco, California, USA.
Cancer cytopathology
|June 8, 2023
概括
尿细胞学 (UC) 中的细胞块 (CB) 制剂有助于诊断,特别是在疑似高度泌尿腺癌 (SHGUC) 时. 这项研究表明,CBs在超过一半的病例中证实了诊断,并在子集中改变了诊断,突出了其实用性.
科学领域:
- 尿路病理学 尿路病理学
- 细胞病理学 细胞病理学
- 在瘤学瘤学.
背景情况:
- 细胞块 (CB) 制剂在尿细胞学 (UC) 中未得到充分利用.
- 在诊断转移性疾病,免疫组织化学 (IHC) 染色和辅助研究方面,CBs有好处.
- 在UC的CB利用中存在基于医院的变化.
研究的目的:
- 评估CB制剂在尿细胞学 (UC) 中的诊断性能.
- 评估CBs在UC内的不同诊断类别中的实用性.
- 为了比较ThinPrep单独与ThinPrep与CB结合的诊断.
主要方法:
- 从三所教学医院对250个UC病例的CB进行了回顾性审查.
- 收集的数据包括患者人口统计,样本类型,原始诊断和IHC染色.
- 与单独使用ThinPrep相比,盲目审查评估了CB实用性,细胞性和对诊断的影响.
主要成果:
- 在61.2%的UC病例中,CB制剂被发现是有用的,最显著的是怀疑高度泌尿腺癌 (SHGUC) 病例 (87.0%).
- 在13.2%的病例中,结合CB改变了诊断,SHGUC的比率更高 (43.5%).
- 膀洗占样本的大多数 (72.1%);IHC染色在17.2%的样本中进行.
结论:
- 在UC中的CB准备在超过一半的病例中证实了最终诊断.
- 对于SHGUC来说,CBs特别有价值,它在一个重要的子集中改变了诊断.
- 建议对受益于CB准备的特定病例类型进行进一步调查.
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