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高海拔OmicsDB是高海拔相关基因和蛋白质,网络和语义相似性的综合资源

Apoorv Gupta¹, Sandhya Pathak¹, Rajeev Varshney¹

¹Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, New Delhi, 110054, India.

Scientific reports

|June 8, 2023

概括

HighAltitudeOmicsDB编译了与高海拔 (HA) 压力相关的验证基因和蛋白质,帮助研究低氧适应. 这个资源提供了蛋白质-蛋白质相互作用和基因本体学相似之处,以获得对HA条件的机械洞察力.

科学领域:

生物医学信息学生物医学信息学
高度生理学高度生理学
基因组学就是基因组学.

背景情况:

全球数百万人经历高海拔 (HA) 环境,需要了解缺氧应激反应.
尽管进行了广泛的研究,但对缺氧适应机制的理解仍然不完全.
识别高海拔疾病的标志物需要对现有研究进行全面分析.

研究的目的:

创建一个集中,精心策划的数据库 (HighAltitudeOmicsDB) 对与HA条件相关的基因/蛋白质.
为了促进对HA压力的诊断,治疗和预测标志物的识别.
为探索生物分子对缺氧反应提供一个用户友好的平台.

主要方法:

经过实验验证的与HA条件相关的基因/蛋白质的汇编.
包括关于蛋白质与蛋白质相互作用 (PPI) 和基因本体学 (GO) 语义相似性的数据.
整合详细的元数据,包括监管水平,暴露条件和实验验证方法.

主要成果:

HighAltitudeOmicsDB提供了一个全面的资源,包含有关HA相关基因/蛋白质的详细信息.
该数据库包括交互式PPI网络和GO语义相似度矩阵.
它整理了疾病/药物关联和途径信息,以进行增强的分析.

结论:

HighAltitudeOmicsDB是研究高海拔生理学和缺氧的研究人员的一个独特平台.
综合数据和分析工具为疾病病理学提供了机械洞察力.
本资源支持对HA相关分子数据的探索和分析.

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