微化结晶学作为DCIS复发的潜在标志物
Sarah B Gosling1, Emily L Arnold2, Samantha K Davies2
1School of Chemical and Physical Sciences, Keele University, Keele, UK. s.b.gosling@keele.ac.uk.
Scientific reports
|June 8, 2023
概括
研究人员在微化中确定了独特的乳腺癌生物标志物. 这些发现可能有助于预测管道癌在现场的进展,并减少过度治疗.
科学领域:
- 在瘤学瘤学.
- 材料科学 材料科学 材料科学
- 生物化学 生物化学
背景情况:
- 管道癌在现场 (DCIS) 占新诊断的乳腺癌的20-25%.
- 侵入性进展风险的不确定性和缺乏生物标志物导致显著的过度治疗 (~75%).
研究的目的:
- 确定DCIS侵袭性进展的新型预后生物标志物.
- 探索DCIS微化的晶体和化学特性,以预测潜力.
主要方法:
- 分析患有或没有侵袭性乳腺癌复发的患者的微化 (5年随访).
- 结晶学特征 (白石质量,晶体成熟度) 和元素组成 (Na/Ca比) 的比较.
主要成果:
- 经常性和非经常性群体之间观察到白石石相对质量和晶体成熟度的显著差异.
- 离子和离子比率的明显差异被发现.
- 一个初步的预测模型为DCIS实现了0.797的AUC,使其成为侵袭性癌症的进展.
结论:
- 根据侵袭性进展风险,DCIS微化成分和结构有所不同.
- 这些特征为DCIS提供了潜在的预后生物标志物.
- 了解微化形成,可以了解瘤微环境.
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