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炎症性肠病的流行病学,验证和临床特征:ABIS出生队列研究
Malin Östensson1, Olle Björkqvist2, Annie Guo3
1Bioinformatics and Data Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
这项研究发现,瑞典儿童的炎症性肠病 (IBD) 累计发病率为0.74%. 基于注册的IBD定义对于队列研究非常有效.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 出生队列研究提供了关于炎症性肠病 (IBD) 的早期决定因素的见解.
- 基于注册的数据往往缺乏临床细节,并且依赖于诊断算法.
- 瑞典东南部所有婴儿 (ABIS) 队列被用来评估IBD登记册数据的有效性.
研究的目的:
- 检查IBD基于注册表的定义的有效性.
- 在瑞典出生队列中确定IBD的发病率和累积发病率.
- 在诊断时描述IBD的临床和治疗特征.
主要方法:
- 使用瑞典国家患者登记册 (NPR) 对16223名儿童从出生 (1997-1999) 到2020年的IBD诊断进行了跟踪.
- 计算IBD发病率和累计发病率.
- 对2017年诊断的病例进行了医疗记录审查,以确定积极预测值 (PPV) 和临床特征.
主要成果:
- 到2020年,有113名参与者 (0.74%) 获得了基于登记的IBD诊断,每10万人/年发生率为31.3.
- 基于注册的IBD定义的PPV为93% (在61个审查的案件中,有57个).
- 在新诊断的克罗恩病 (CD) 中,生物药物比性结肠炎 (UC) 更常见;平均便calprotectin随着时间的推移显著下降.
结论:
- 在这个基于瑞典人口的样本中,IBD的累积发病率为0.74%.
- 基于注册的IBD定义显示了高的有效性.
- 注册数据适合在大型队列研究中识别IBD患者.
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