贝瓦西祖马布后的胃肠道穿孔:一个多地点,单一机构的研究,重点是生存率
Michael H Storandt1, Nguyen H Tran2, Christopher J Ehret2
1Department of Medicine, 200 First Street SW, Rochester, MN, 55905, USA.
World journal of surgical oncology
|June 8, 2023
概括
贝瓦西祖马布诱导的胃肠道穿孔是罕见但严重的. 手术改善了生存率,而皮质类固醇使用使其恶化,为患者管理提供了关键数据.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 临床药理学 临床药理学
背景情况:
- 贝瓦西祖马布 (Avastin) 是一种用于癌症治疗的单克隆抗体.
- 胃肠道穿孔是一种罕见但严重的不良事件,与贝瓦西祖马布治疗有关.
- 关于患有贝瓦齐祖马布诱导的胃肠道穿孔的患者的整体存活期的数据有限.
研究的目的:
- 调查和报告癌症患者的生存结果,这些癌症患者在接受贝瓦西祖马布治疗后发生了胃肠道穿孔.
- 为了确定与改善或恶化的生存相关的因素后,贝瓦齐祖马布诱导的胃肠道穿孔.
主要方法:
- 追溯性,多个地点,单一机构的研究.
- 纳入标准:接受贝瓦齐祖马布治疗的癌症患者,有记录的胃肠道穿孔 (2004年1月至2022年1月).
- 使用卡普兰-梅尔曲线和考克斯比例危险模型进行生存分析.
主要成果:
- 包括89名患者;中位数年龄62岁;结直肠癌最常见 (42%).
- 平均整体存活期为2.7个月;36%的人在穿孔后30天内死亡.
- 手术与显著改善的生存率相关 (HR 0.47,p=0.002);皮质类固醇使用与更差的生存率相关 (HR 1.75,p=0.04).
结论:
- 贝瓦西祖马布诱导的胃肠道穿孔需要个性化管理.
- 这项研究提供了关键的生存数据,以指导患者,家庭和医疗保健提供者的临床决策.
- 手术干预和避免使用皮质类固醇可能会对结果产生积极影响.
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