在治疗心病期间对27只客户拥有的狗进行值的评估
C Autumn M Vetter1, Alison G Meindl2, Bianca N Lourenço3
1Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA. cam18@uga.edu.
Parasites & vectors
|June 8, 2023
概括
使用美国心学会 (AHS) 协议的狗心病 (CHD) 治疗没有显著影响功能标志物,包括对称二甲基氨酸 (SDMA). 这项研究监测了在成年杀毒药治疗期间的SDMA和肌素水平,没有发现功能存在实质性变化.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 寄生虫学的寄生虫学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 由Dirofilaria immitis引起的狗心病 (CHD) 是美国普遍存在且日益关注的问题.
- 目前美国心学会 (AHS) 的治疗包括宏环酸乳,多西环素和米拉索胺,可能会导致并发症.
- 损伤是已知的心血管疾病的系统性影响,由脏生物标志物升高表明,但在治疗期间对称二甲基氨酸 (SDMA) 的变化尚未研究.
研究的目的:
- 评估正在接受针对心脏病治疗的成年杀虫剂治疗的狗的功能.
- 在治疗的各个阶段测量血清肌素和对称二甲基氨酸 (SDMA) 度.
主要方法:
- 血清肌素和SDMA在27只患有心血管疾病的狗身上在基线,在抗生素治疗期间以及在 melarsomine 管理期间的多个点上进行了测量.
- 在治疗后1-6个月的后续访问中也进行了测量.
- 混合效应线性模型被用来比较时间点之间的生物标志物度.
主要成果:
- 与基线相比,第二剂梅拉索明后的SDMA平均度显著降低 (-1.80 ug/dL,P=0.00829).
- 在基线和其他治疗时间点之间没有观察到其他具有统计意义的肌素或SDMA差异.
- 这些发现表明AHS协议期间对功能标志物的影响最小.
结论:
- 目前针对狗心病的AHS治疗方案似乎对功能没有实质性的影响.
- 监测SDMA和肌素可以了解心血管疾病治疗期间的脏健康状况.
- 进一步的研究可能会探索长期的效应或替代治疗的影响.
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