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用免疫检查点抑制剂治疗的不同癌症实体中的伪进展模式
Sebastian Mönch1, Maurice M Heimer1, Michael Winkelmann1
1Department of Radiology, University Hospital, LMU Munich, Marchioninistr. 15, Munich, 81377, Germany.
概括
伪进展 (PsPD) 是免疫检查点抑制剂 (ICI) 治疗的罕见反应. 像病变进展和新病变这样的成像特征是常见的,有时与免疫相关的不良事件 (irAE) 相相关.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 免疫治疗是一种免疫疗法.
背景情况:
- 伪进展 (PsPD) 是一种不常见的反应模式,在免疫检查点抑制剂 (ICI) 治疗期间观察到.
- 了解PsPD的成像特征对于准确的治疗评估至关重要.
研究的目的:
- 在接受ICI治疗的患者中识别与PsPD相关的成像特征.
- 探索PsPD和其他临床发现,如瘤标志物和免疫相关不良事件 (irAE) 之间的相关性.
主要方法:
- 对32名患有PsPD的患者进行了回顾性分析,这些患者接受了至少三项成像研究.
- 使用固体瘤免疫反应评估标准 (iRECIST) 评估治疗反应.
- 对目标病变 (TL),非目标病变 (NTL),新病变 (NL),瘤标志物和irAE.的分析.
主要成果:
- 在第一次随访 (FU1) 时,psdp最常见,在81.3%的患者中观察到.
- 常见的成像发现包括TL (37.5%),NTL (21.9%) 和新病变 (18.8%) 的增加.
- 在43.8%的患者中,PsPD与irAE相关;瘤标志物仅在10.5%的病例中升高.
结论:
- PsPD通常在ICI治疗的早期表现出来,主要是由于TL和NTL的进展.
- 虽然瘤标志物可能并不总是上升,但PsPD似乎与irAE有关.
- 这些成像见解可以帮助临床决定关于ICI延续.
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