后急性COVID-19三剂接种疫苗的自身免疫性风湿性疾病患者:这种情况的频率和模式
Clovis Artur Silva1,2, Leonard de Vinci Kanda Kupa1, Ana Cristina Medeiros-Ribeiro1
1Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Arnaldo, 455, sala 3190 - Cerqueira César, São Paulo, SP, 01246-903, Brazil.
Advances in rheumatology (London, England)
|June 8, 2023
概括
后急性COVID-19发生在接种疫苗的自身免疫性类风湿性疾病患者和对照组中类似. 在自身免疫性类风湿性疾病中,免疫系统障碍似乎没有显著影响COVID-19后的条件.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
背景情况:
- 有限的数据存在于后急性COVID-19在自身免疫性类风湿性疾病 (ARD).
- 之前的研究使用了对后急性COVID-19和疫苗接种时间的各种定义.
- 这项研究解决了在接种疫苗的ARD患者中需要明确数据的需求.
研究的目的:
- 确定后急性COVID-19的频率和特征.
- 为了比较接种疫苗的ARD患者与非ARD对照者的结局.
- 利用已建立的诊断标准,用于后急性COVID-19的诊断.
主要方法:
- 预期队列的回顾性分析.
- 108名ARD患者和32名非ARD对照在第三剂疫苗接种和SARS-CoV-2感染后.
- 后急性COVID-19被定义为持续超过4周和12周的症状.
主要成果:
- 在ARD患者和对照者之间,可比的后急性COVID-19 (≥4周和>12周) 发生频率.
- 在两个时间点的两个群体中,症状负担相似 (≥3个症状).
- 年龄,性别,COVID-19严重程度,再感染和自身免疫性疾病状态不是急性后COVID-19的风险因素.
结论:
- 后急性COVID-19模式在接种疫苗的ARD患者和一般人群中是相似的.
- 在ARD中,免疫/炎症障碍似乎不是急性后COVID-19的主要决定因素.
- 新的数据支持这些群体中COVID-19后条件的相似性.
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