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严重肥胖的脏捐赠者在脏移植前进行腹腔外科手术:一项回顾性研究
Dana Bielopolski1,2, Renana Yemini3,4, Aviad Gravetz2,5
1Department of Nephrology and Hypertension, Rabin Medical Center, Petah-Tikva, Israel.
Transplantation
|June 9, 2023
概括
在脏捐献之前的腹腔外科手术是安全的,可能会扩大捐赠者群. 然而,捐赠者应在手术后管理体重和脂质概况,以保持长期健康.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 腹部外科 腹部外科
- 移植 移植 移植 移植
背景情况:
- 腹腔外科手术 (BS) 是有效的减肥和可能会影响脏捐赠者资格.
- 评估切除术后BS对捐赠者的代谢和功能的长期影响至关重要.
研究的目的:
- 为了评估长期的新陈代谢概况和活捐赠者的功能,在切除术之前接受了减肥手术.
- 为了将这些结果与单独接受减肥手术或单独接受切除术的对照组进行比较.
主要方法:
- 单一中心的回顾性研究将脏捐赠者 (BS然后是切除术) 与对照者 (单独的BS或单独的切除术) 相匹配.
- 关键指标包括体重指数,血清脂质,糖尿病状况和功能 (eGFR,绝对eGFR).
主要成果:
- 与单独使用BS组相比,BS-before-nephrectomy组显示出较差的脂质特征 (较高的LDL和总胆固醇).
- 功能 (肌素,eGFR,绝对eGFR) 与非肥胖的捐赠者在腎切除术前和后的情况相似.
- 与对照组相比,研究组在腎切除术后表现出明显更高的绝对eGFR.
结论:
- 在活体脏捐赠之前的腹腔外科手术似乎是安全的,并且可能会扩大捐赠者群.
- 为长期的供体健康,建议鼓励体重维持和监测脂质概况和过.
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