在双重肺移植后的通风-输液扫描上相对肺 perfusion
David J Li1, Jonathan Abele2, Parveen Sunner2
1Department of Medicine, University of Alberta, Edmonton, Canada.
Transplantation
|June 9, 2023
概括
肺移植后肺 perfusion 差异较大是常见的,并且与较高的死亡风险,慢性肺异位功能障碍 (CLAD) 和较差的肺功能有关. 这一发现凸显了对其预测价值的进一步研究的需要.
科学领域:
- 肺部医学 肺部医学
- 移植手术 移植手术 移植手术
- 放射学 放射学是一门学科.
背景情况:
- 肺部血流的评估是使用通风 perfusion (VQ) 扫描.
- 在肺 perfusion 中,正常的右向左差异通常为55%至45% (10%).
- 肺移植后的广泛输液差异可能表明不良结果.
研究的目的:
- 为了研究肺移植后3个月的VQ扫描和结果之间的广泛输液差异之间的关联.
- 为了确定输液差异是否预测死亡,再移植,慢性肺异位移植功能障碍 (CLAD) 或基线肺异位移植功能障碍.
主要方法:
- 双肺移植接受者的回顾性队列研究 (2005-2016).
- 在3个月的VQ扫描中,鉴定出患有输液差异>10%的患者.
- 使用生存分析 (Kaplan-Meier,比例危险) 和回归模型来评估结果.
主要成果:
- 49%的患者 (169/340) 在3个月后表现出≥10%的输液差异.
- 增加的输液差异与较高的死亡/再移植风险 (P=0.011) 和CLAD发病风险 (P=0.012) 显著相关.
- 更广泛的输液差异与扫描时的肺功能下降相关.
结论:
- 广泛的肺 perfusion 差异是一个经常发现的肺移植后的发现.
- 这种异常与死亡率增加,肺功能减弱和CLAD的更高率有关.
- 需要进一步的研究,以了解 perfusion 差异的临床意义和预测效用.
更多相关视频
09:54Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
Published on: August 15, 2022
1.9K
09:31Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
Published on: February 14, 2022
2.2K
相关概念视频
01:30Radiological Investigation II: MRI and Ventilation Perfusion Scan
156
Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
156
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
117
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
117