食欲和口渴不需要在星球细胞或肝细胞中产生血管激素
Lila Peltekian1, Silvia Gasparini1, Frederico S Fazan1
1Department of Neurology, University of Iowa, Iowa City, IA, USA.
The Journal of physiology
|June 9, 2023
概括
对口渴或食欲不需要 ангиотензин信号传递. 大脑或肝脏中的血管激素原基因 (Agt) 的遗传删除没有影响这些行为,这表明涉及其他机制.
科学领域:
- 神经科学是一个神经科学.
- 生理学 生理学 生理学
- 内分泌学 在内分泌学.
背景情况:
- ангиотензин信号传递与低血压期间调节盐和水摄入有关.
- 对于这些行为在大脑或肝脏中产生血管素的具体要求仍然不清楚.
研究的目的:
- 调查大脑或肝脏中的血管素生产是否对食欲和口渴至关重要.
主要方法:
- 在现场杂交以识别血管激素前体和酶的基因表达.
- 在小鼠的特定组织 (大脑星球细胞,肝脏肝细胞) 中,血管激素原基因 (Agt) 的条件遗传删除.
主要成果:
- Agt,Ren1和Ace基因在特定的大脑区域 (星细胞,胸膜,模糊核) 和肝脏中表达.
- 在大脑星球细胞中删除Agt并没有减少口渴或食欲.
- 肝脏特异性的Agt删除,减少循环中的血管素,并没有降低口渴或食欲;相反,它增强了它们.
- 在大脑和肝脏中Agt的联合删除也未能防止口渴或食欲.
结论:
- 血管素信号不需要调节口渴和食欲,以应对低血压.
- 这些发现需要确定负责调节这些基本行为的替代信号通路.
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