SARS-CoV-2 感染是垂体中风的危险因素? 一个案例系列和文献综述
Christina Hazzi1, Noémie Villemure-Poliquin1, Sylvie Nadeau1
1Department of Ophthalmology and Otolaryngology-Head and Neck Surgery, CHU de Québec, Quebec, QC, Canada.
Ear, nose, & throat journal
|June 9, 2023
概括
垂体脑梗塞 (PA) 是一种罕见的垂体腺事件,越来越多地与COVID-19有关. 这项研究增加了三个病例,表明COVID-19可能直接导致PA,可能是由于凝血病,突出显示了一种新的临床关联.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 垂体中风 (PA) 是一种罕见的内分泌紧急情况,涉及垂体腺出血或心脏病发作.
- 由SARS-CoV-2引起的COVID-19具有不同的临床表现.
- 已经注意到COVID-19感染和PA之间的新兴关联,但因果关系尚不清楚.
研究的目的:
- 报告与COVID-19和PA同时发生的患者的额外病例.
- 审查有关COVID-19相关的PA的现有文献.
- 讨论这种关联的潜在机制,治疗方法和结果.
主要方法:
- 从2020年3月到2021年12月,对PA和COVID-19患者的电子图表审查.
- 通过使用MEDLINE,Web of Science和Embase进行全面的文献搜索.
- 对临床表现,管理和结果的分析.
主要成果:
- 在症状性COVID-19感染后发现了三例新的PA病例.
- 由于持续的视力缺陷,两名患者需要手术干预.
- 文献审查发现了12个额外的病例,使报告的总数达到15.
- 在COVID-19感染后几天到两个月发生PA症状.
结论:
- 越来越多地认识到COVID-19和PA之间的关联,目前报告了15起病例.
- 凝血病是可能导致COVID-19患者垂体出血或心脏病发作的机制.
- 下垂体脑梗塞可能是COVID-19感染的直接表现.
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