通过合理的组合和生物标志物,在胃食道癌症中推进免疫治疗
Bulent Cetin1, Chiara A Wabl2, Ozge Gumusay3
1Department of Internal Medicine, Division of Medical Oncology, Ondokuz Mayıs University, Faculty of Medicine, Samsun, 55280, Turkey.
Immunotherapy
|June 9, 2023
概括
检查点抑制剂彻底改变了胃食道癌症的治疗方法,成为标准的第一线治疗方法. 将化疗与免疫疗法结合使用,可改善晚期食道癌和胃癌的治疗结果.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 近年来,检查点抑制剂显著提高了胃食道癌症的治疗水平.
- 具有里程碑意义的试验,如KEYNOTE-590,CHECKMATE 649和CheckMate 648,确立了免疫疗法作为一线治疗.
- 这导致了管理晚期食道和胃癌的范式转变.
研究的目的:
- 审查免疫治疗对胃食道癌症治疗的影响.
- 突出目前的高级疾病护理标准.
- 讨论基于生物标志物的治疗选择的重要性.
主要方法:
- 对具有里程碑意义的临床试验进行审查 (KEYNOTE-590,CHECKMATE 649,CheckMate 648).
- 对晚期胃食道腺癌的当前治疗标准的分析.
- 讨论新兴的治疗点和瘤微环境的作用.
主要成果:
- 免疫疗法,特别是与化疗相结合,现在是局部晚期或转移性食道,食道胃结和胃腺癌的标准第一线治疗方法.
- 基于癌细胞和瘤微环境的表征,新的治疗点和治疗方法正在出现.
- 生物标志物驱动的选择对于优化患者的治疗结果和最大限度地减少毒性至关重要.
结论:
- 免疫疗法代表了胃食道癌症治疗的重大进步.
- 使用生物标志物的个性化治疗策略对于提高疗效和安全至关重要.
- 对新型点和治疗顺序的进一步研究将继续改进患者管理.
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