Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Gene-Environment Interactions01:20

Gene-Environment Interactions

376
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
376
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

6.6K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.6K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.7K
Factors affecting Blood pressure01:28

Factors affecting Blood pressure

3.4K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
3.4K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

13
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
13
Polygenic Traits01:18

Polygenic Traits

66.1K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
66.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

[Parent-of-origin effects of FGF/FGFR signaling pathway candidate gene polymorphisms on the risk of non-syndromic cleft lip with or without cleft palate].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2025
Same author

[Research progress on precise lifestyle intervention for obesity based on genetic background].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2025
Same author

[Chinese translation of European Respiratory Society guidelines for the diagnosis and management of pulmonary alveolar proteinosis].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2025
Same author

[Parent-of-origin effect and its research progress in cardio-metabolic diseases].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2025
Same author

[Association between short-term ambient air pollution exposure and arterial stiffness and effect modification of obesity].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2024
Same author

[Chronic airway diseases: a new frontier in interventional pulmonology].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2024

相关实验视频

Updated: Jul 27, 2025

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

16.1K

[基因型与环境对动脉硬性的相互作用:基于血统的研究]

X H Wang1, S Y Wang1, H X Peng1

  • 1Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
|June 9, 2023
PubMed
概括

健康的生活方式,特别是饮食和健康的体重指数 (BMI),可以降低动脉硬的遗传风险. 特定的基因变异与生活方式因素相互作用,影响动脉硬的风险.

关键词:
动脉的硬性 动脉的硬性基因与环境的相互作用.生活方式 生活方式祖父的血统是什么意思

更多相关视频

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

10.6K
Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

17.6K

相关实验视频

Last Updated: Jul 27, 2025

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

16.1K
Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

10.6K
Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

17.6K

科学领域:

  • 心血管健康 心血管健康
  • 遗传学 遗传学 是一个
  • 流行病学 流行病学

背景情况:

  • 动脉硬是心血管风险的一个关键指标.
  • 遗传因素和生活方式的选择都会影响动脉硬.
  • 了解基因与环境的相互作用可以为个性化预防策略提供信息.

研究的目的:

  • 调查遗传因素是否会改变健康生活方式与动脉硬之间的关联.
  • 为了确定涉及与动脉硬相关的基因环境相互作用的特定遗传位置.

主要方法:

  • 利用了来自北京方山家庭队列研究的基线数据.
  • 发展了健康的生活方式得分 (饮食,BMI,吸烟,酒精,体育活动).
  • 使用腕脉冲波速率 (baPWV) 和脚腕指数 (ABI) 评估动脉硬度.
  • 采用遗传性差异组件模型和基因型与环境相互作用的最大概率方法,包括对特定SNP的分析.

主要成果:

  • baPWV和ABI的遗传性是显著的 (分别为0.360和0.243).
  • 在baPWV上发现了显著的基因型-饮食相互作用,在ABI上发现了基因型-BMI相互作用.
  • 确定了五个SNP (在ADAMTS9-AS2,CDH13,CDKAL1,ATP8B2,SLC30A8中),这些SNP修改了健康饮食/BMI和动脉硬之间的关系.

结论:

  • 基因型-饮食模式和基因型-BMI相互作用在动脉硬风险中起作用.
  • 健康的生活方式,特别是饮食和保持健康的BMI,可以减轻对动脉硬的遗传倾向.
  • 确定了关键的遗传位置,为未来对动脉硬机制的研究提供了基础.