在2型糖尿病中发生的异质性脂质血症:PREDISAT研究
Elisenda Climent1, Jesús Millán2,3, Juan F Ascaso4
1Department of Endocrinology and Nutrition, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.
Lipids
|June 9, 2023
概括
动脉性脂质失调 (AD) 影响超过40%的西班牙2型糖尿病 (T2DM) 患者,特别是年轻人. 虽然治疗减少了患病率,但许多人仍然只接受他单一治疗.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 动脉性脂质失调症 (AD) 在2型糖尿病 (T2DM) 中很常见,但患病率有很大差异.
- 了解T2DM中AD的流行率和特征对于心血管风险管理至关重要.
研究的目的:
- 为了确定在西班牙T2DM受试者中AD的患病率.
- 为了比较AD和没有AD的T2DM患者之间的临床特征.
- 在临床实践中分析脂质特征变化和降脂治疗模式.
主要方法:
- 一项多中心子研究 (PREDISAT) 使用来自国家脂质不良病登记册的数据.
- 包括385名T2DM患者 (年龄≥18岁),平均随访时间为22个月.
- 评估阿尔茨海默病的患病率,脂质概况和治疗策略.
主要成果:
- 在基线时,41.3%的T2DM患者患有AD,治疗后降至34.8%.
- 在年轻的T2DM个体中,AD的患病率更高.
- 尽管治疗率高 (90%),但阿尔茨海默病患者表现出更高的动脉质脂质样本和低于最佳的目标实现,其中大多数是使用他单疗法.
结论:
- 在西班牙T2DM患者中,阿尔茨海默病的患病率很高,受年龄的影响.
- 治疗干预表明,阿尔茨海默病患病率略有下降.
- 目前的降脂治疗,主要是单独使用他类药物治疗,在许多患有AD的T2DM患者中,似乎不足以实现脂质目标.
更多相关视频
07:29Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
9.3K
10:17An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
7.1K
相关概念视频
01:22Diabetes Mellitus: Type 2 and Gestational
2.6K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
205
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
205
01:30Atherosclerosis I: Introduction
13
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
13
01:30Coronary Artery Disease I: Introduction
33
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
33
01:26Atherosclerosis III: Management
15
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
15
01:26Coronary Artery Disease II: Pathophysiology
15
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
15